Kajian Potensi Kayu Manis dan Teh sebagai Pangan Antidiabetes

Authors

  • Nawasari Indah Putri S. Jurusan Gizi Poltekkes Tanjungkarang

DOI:

https://doi.org/10.26630/jk.v9i3.874

Keywords:

Antioxidant, Cinnamon, Tea, Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. Type 2 Diabetes Mellitus (T2DM) can be controlled by healthy food and adequate physical activities. Some foods can be used for diabetes control such as cinnamon and tea. This paper determined to study cinnamon and tea researches as an antidiabetic food. All researches about cinnamon and tea as an antidiabetic were collected. It was found that cinnamon (Cinnamomum burmanii Blume) and tea (Camelia sinensis L) have many health potentials, such as antioxidants, antibacterial, antidiabetic. Cinnamon shows the ability to lower fasting blood glucose, HbA1c, and plasma lipids; altered postprandial glucose patterns, increased antioxidants and decreased plasma inflammatory markers. In the other hand, tea as the second most consumed drinks in the world could preventing or controlling diabetes with decrease digestive enzyme and intestinal GLUT activity, decrease gluconeogenesis gene expression, increase insulin sensitivity,  and protect beta pancreatic. Tea can prevent the risk of T2DM disease if consumed as much as 3 cups per day. It was concluded that both foods can be used to control type 2 diabetes mellitus if consumed in an adequate amount.

 

References

Akilen R, Tsiami A, Devendra D, Robinson N. 2010. Glycated haemoglobin and blood pressure lowering effect of cinnamon in multi-etnic type 2 diabetic patients in the UK: a randomized, placebo controlled, double blind clinical trial. Diabet Med. 27 (10): 1159–1167.

Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. 2007. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care. 30(4):813–816.

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ. 2004. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem.52 (1) : 65–70.

Blocks W. 2009. The antidiabetes trigger. Life enhancement magazine. New York: Life Enhancement Product Inc

Bryans JA, Judd PA, Ellis PR. 2007. The effect of consuming instant black tea on postprandial plasma glucose and insulin concentrations in healthy humans. J Am Coll Nutr. 26(5): 471-477.

Cai EP dan Lin JK. 2009. Epigallocatechin gallate ad rutin suppress tea glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cell. J Agric Food Chem. 57 (20): 9817–9827.

Cao H, Polansky MM, Anderson RA. 2007. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. J Archives of Biochem and Biophys 459 (2): 214 – 222.

Cao H, Urban Jr JE, Anderson RA. 2008. Cinnamon polyphenol extract affects immune responses by reglukosating anti- and proinflammatotry and glucose transporter gene expression in mouse macrophages. J of Nutr. 138(5): 833–840.

Cheng DM, Kuhn P, Poulev A, Rojo LE, Lila MA, dan Raskin L. 2012. In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. J. Food Chem. 135 (4): 2994–3002.

Crawford P. 2009. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized controlled trial. J. Am. Board Fam Med. 22(5): 507–512.

Fu Z dan Zhen W. 2010. Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice. Br J Nutr. 105(8):1218 – 1225

Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H. 2008. Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur J of Clin Nutr. 62(8): 953–960.

Grant P and Dworakowska D. 2013. Tea and diabetes: the laboratory and the real world in Tea in Health and Disease Prevention. New York: Elsevier Inc.

Handberg A, Levin K, Hojlund K, Beck-Nielsen H. 2006. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation. 114(11):1169-1176.

Hartoyo A, Sukarno, dan Rohmawati E. 2010. Pengaruh fraksinasi non protein kacang komak (Lablab purpureus L. Sweet) terhadap kadar glukosa darah dan malonaldehid tikus diabetes. J Tek dan Ind Pangan. 21(1): 40–44.

Hininger-Favier I, Benaraba R, Covers S, Anderson RA, dan Roussel AM. 2009. Green tea extract decrease oxidative stress and improve insulin sensitivity in an animal model of insulin resistance, the fructose-fed rats. J Am Coll Nutr. 28(4): 355–361.

Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. 2007. Effect of cinnamon on postprandial blood glucose, gastric emptying and satiety in healthy subjects. Am J Clin Nutr. 85 (6): 1552–1556

Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, and Holst JJ. 2009. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 89 (3) : 815-821.

Hosoda K, Wang MF, Liao ML, Chuang CK, Iha M, Clevidence B, Yamamoto S. 2003. Antihyperglycemic effect of oolong tea in type 2 diabetes. Diabetes Care. 26 (6): 1714–1718.

International Diabetes Federation [IDF]. 2017. Diabetes Atlas 8th ed. London. UK. Tersedia di www.diabetesatlas.org/

Jing Y, Han G, Hu Y, Bi Y, Li L Zhu D. 2009. Tea consumption and risk of type 2 diabetes: a meta-analysis of cohort studies. J Gen Intern Med. 24(5): 557–562.

Josic J, Olsson AT, Wickeberg J, Lindstedt S, dan Hlebowizc J. 2010. Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. J Nutr. 30(9): 63.

Junli Lv, Huang H, Yu L, Whent M, Niu Y, Shi H, Wang TTY, uthria D, Charles D, Yu LL. 2012. Phenolic composition and nutraceutical properties of organic and conventional cinnamon and peppermint. J Food Chem. 132 (3): 1442-1450.

Kao YH, Chang HH, Lee MJ, dan Chen CL. 2006. Tea, obesity, and diabetes: Review. J Mol Nutr Food Res. 50(2): 188-220.

Khan A, Safdar M, Ali Khan MM, Khattak KN, and Anderson RA. 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 26(12): 3215-3218.

Kirkham S, Akilen R, Sharma S, dan Tsiami A. 2012. The potential of cinnamon to reduce blood glucose levels in patienets with type 2 diabetes and insulin resistance. J Diab, Obes and Metab. 11(12): 1100-111.3

Lacaille-Dubois MA, Franck U, and Wagner H. 2001. Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. J Phytomedicine. 8(1): 47-52.

Lazo-de-la-Vega-Monroy M dan Fernández-Mejía C. 2013. Oxidative stress in diabetes mellitus and the role of vitamins with antioxidant actions. In:Oxidative Stress and Chronic Degenerative Diseases-ARole for Antioxidants, Dr. Jose Antonio Morales-Gonzalez (Ed.). InTech. DOI: 10.5772/51788.

Li R, Liang T, Xu L, Li Y, Zhang S, Duan X. 2013. Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high sugar, high fat diet and its underlying mechanism. J. Food and Chem Toxic.51(1): 419-425.

Lin CL dan Lin JK. 2008. Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human HepG2 hepatoma cells. Mol Nutr Food Res. 52(8): 930-939.

Lu J, Zhang K, Nam S, Anderson RA, Jove R, Wen W. 2010. Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis. 31(3):481–488.

Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y. 2012. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. J Nutres. 32(6): 408–412.

MacKenzie T, Leary L, dan Brooks WB. 2006. The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes melitus: double blind randomized study. J Metab Clin and Exp. 56(10): 1340-1344.

Magistrelli A dan Chezem JC. 2012. Effect of ground cinnamon on postprandial blood glucose concentration in normal weight and obese adults. J AcNutr and Diet. 112(11): 1806-1809.

Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. 2006. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes melitus type 2. Eur J of Clin Invest. 36(5): 340-344.

Mohamed S. 2014. Functional foods against metabolic syndrome (obesity, diabetes, hypertension and dyslipidemia) and cardiovascular disease. J Trends in Food Sci & Tech. 35(2): 114–128

Murase T, Misawa K, Haramizuki S, Dan Hase T. 2009. Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway.Biochem Parmacol. 78(1): 78–84.

Najm W and Lie D. 2010. Herbal use for diabetes, obesity, and metablic syndrome. J Prim Care Clin Off Pract. 37(2): 237-254.

Oba S, Nagata C, Nakamura K, Fujii K, Kawachi T, Takatsuka N, Shimizu H. 2010. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Br J Nutr. 103(3): 453-459.

Park JH, Bae JH, Im SS, and Song DK. 2014. Green tea and type 2 diabetes: A review. J Integrative Med Res. 3(1): 4-10.

Peng X, Cheng KW, Ma J, Chen B, Ho CT, Lo C, Chen F, Wang M. 2008. Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. J Agric Food Chem. 56(6):1907-1911.

Perkumpulan Endokrinologi Indonesia [PERKENI]. 2011. Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia.

Ping H, Zhang G, dan Ren G. 2010. Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice. J Food and ChemToxico. 48(8-9): 2344-2349.

Prangdimurti E, Muchtadi D, Astawan M, Zakaria FR. 2006. Aktivitas antioksidan ekstrak daun suji (Pleomele angustifolia N.E. Brown). J. Teknol dan Industri Pangan, 17(2): 79-86.

Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. 2003. Cinnamon extract (traditional herb) potentiates in vivo insulin-reglukosated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract. 62(3):139-148.

Qin B, Panickar KS, and Anderson RA. 2010a. Cinnamon: Potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 4(3): 685-692.

Qin B, Polansky MM, Anderson RA. 2010b. Cinnamon extract reglucosates plasma levels of adipose-derived factors expression of multiple genes related to carbohydrates metabolism and lipogenesis in adipose tissue of fructose-fed rats. Horm Metab Res. 42(3): 187–193.

Rafehi H, Ververis K, dan Karagiannis TC. 2012. Controversies surrounding the clinical potential of cinnamon for the management of diabetes : Review article. Diabetes, Obesity and Metabolism, 14 (6): 493-499.

Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. 2009. Antioxidant effects of cinnamon extract in people with impaired fasting glucose that are overweight or obese. J. Am Cloo Nutr. 28(1): 16–21.

Rudkowska I. 2009. Functional food for health: focus on diabetes. J. Maturitas. 62(3): 263–269.

Ryu OH, Lee J, Lee KW, Kim HY, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM. 2005. Effects of green tea consumption on inflamation, insulin resistance and pulse wave velocity in type 2 diabetes patients. J Diabet Res and Clin Pract. 71(3): 356-358.

Sejati NIP, Prangdimurti E, dan Zakaria FR. 2016. Pengaruh minuman diperkaya cinnulin terhadap MDA dan senyawa inflamasi plasma penderita DMT2. Jurnal Teknologi dan Industri Pangan, 27(1): 51 – 58.

Sejati NIP. 2016. Pengaruh Minuman yang Diperkaya Cinnulin terhadap Parameter Diabetik Responden Diabetes Melitus Tipe-2. [Tesis]. Bogor: Ilmu Pangan. Program: Pascasarjana Institut Pertanian Bogor.

Solomon TP, Blannin AK. 2007. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 9(6).

Solomon TP, Blannin AK. 2009. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 105(6):969–976.

Spadiene A, Savickiene N, Ivanauskas L, Jakstas V, Skesters A, Silova A, Rodovicius H. 2014. Antioxidant effects of Camelia sinensis L. extract in patients with type 2 diabetes. J of Food and Drug Anal.22(4): 505-511.

Stoecker BJ, Zhan Z, Luo R, Mu X, Guo X, Liu Y, Guo Q, Kong J, Anderson RA. 2010. Cinnamon extract lowers blood glucose in hyper-glycemic subjects [abstract]. FASEB J. 24(1):1

Suppapitiporn S, Kanpaksi N, Suppapitiporn S. 2006. The effect of Cinnamon cassia powder in type 2 diabetes mellitus. J Med Assoc Thai.89 (3): S200–S205.

Tang M, Larson-Meyer DE, Liebman M. 2008. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. Am J Clin Nutr. 87(5): 1262–1267.

Thomas J dan Kuruvilla KM. 2012. Cinnamonin Peter KV (ed.) Handboook of Herbs and Spices. Cambridge:Woodhead Inc.

Thondre PS. 2013. Food base ingredients to modulate bloog glucose. J Adv in Food and Nutr Res. 70(1): 181-227.

van Dieren S, Uiterwaal CS, van der Schouw YT, van der A DL, Boer JMA, Spijkerman A, Grobbee DE, Beulens JWJ. 2009. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia 52(12): 2561-2569.

Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, Van Loon IJ. 2006. Cinnamon supplementation does not improve glycemic control in post menopausal type 2 diebetes patients. J. Nutr. 136(4): 977–980.

Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, and Granner DK. 2002. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 277(38): 34933–34940.

Wang JG, Anderson RA, Graham 3rd GM, Chu MC, Sauer MV, Lobo RA. 2007. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 88(1):240–243.

Wolfram S, Raederstorff D, Preller M, Wang Y, Teixeira SR, Riegger C, Weber P. 2006. Epigallocatechin gallate supplementation alleviates diabetes in rodents. J Nutr. 136(10): 2512–2518.

Wu LL, Chiou CC, Chang PY, Wu JT. 2004. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atehrosclerosis and diabetics. Clin. Chim. Acta. 339(1-2): 1–9.

Yang J, Mao QX, Xu HX, Ma X, Zheng CY. 2014. Tea consumption and risk of type 2 diabetes melitus: a systematic review and meta-analysis update. BMJ open. 4: 1–12.

Zatalia SR dan Sanusi H. 2013. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Medica Indonesiana, 45(2): 141-147.

Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, and Anderson RA. 2006. Effect of water soluble cinnamon extract on body composition and features of teh metabolic syndrome in prediabetic men and women. J Intl Society of Sports Nutr. 3(2): 45-53.

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Published

31-12-2018