Development of an Anti-Acne Facial Wash Gel with Cassia alata L. Leaf Extract
DOI:
https://doi.org/10.26630/jk.v15i1.4224Keywords:
Antibacterial; Ketepeng Plant (Cassia alata L.); Skin disease.Abstract
Acne is a skin disease that is often encountered. Acne can be caused by various factors, including bacterial infection. To prevent acne, keep facial skin clean using facial wash. Using facial wash made from synthetic substances can cause more significant side effects than natural ingredients, so research is needed on natural ingredients that can be used as anti-acne agents. One natural ingredient that has antibacterial activity is ketepeng leaf (Cassia alata L.). This research aims to formulate a facial wash gel preparation from ketepeng leaf extract and test its antibacterial activity against Staphylococcus aureus bacteria. This research is experimental research starting from making extracts, dosage formulation, evaluating the physical properties of the dosage (stability test, organoleptic test, homogeneity test, pH test, viscosity test, spreadability test, and foamability test), skin irritation test, hedonic test and antibacterial activity against Staphylococcus aureus bacteria. The research results showed that the inhibition zone produced by formula 1 was 9.73mm, formula 2 was 10.33mm, and formula 3 was 13.18mm. This research concludes that Ketepeng leaf can be used as an active ingredient in anti-acne facial wash gel preparations because the Ketepeng leaf extract facial wash gel preparation meets the requirements for evaluating good physical properties and has antibacterial activity against Staphylococcus aureus bacteria in each formula.
References
Afita, L. N., Aufa, A., Mardiantik, R. K., & Fatmawati, N. (2021). Formulasi dan evaluasi sediaan gel facial wash ekstrak etanol biji pinang (Areca catechu). Sekolah Tinggi Ilmu Kesehatan Bhakti Mandala Husada Slawi, 2(5), 1–5.
Bayti, N., Purwanto, A., & Ariyani, H. (2021). Formulas dan uji sifat fisik seeding cosmetic facial wash gel dari ekstrak daun kelor (Moringa oleifera lam) dengan variasi konsentrasi carbopol. Journal of Current Pharmaceutical Sciences, 5(1), 464-470.
Dwiastuti, R., & Ardiyati, S. E. (2020). Formulasi sediaan gel nanopartikel lipid ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis).. Pharmacy Medical Journal, 3(2), 40–46.
Egra, S., Mardiana, M., Kurnia, A., Kartina, K., Murtilaksono, A., & Kuspradini, H. (2019). Uji potensi ekstrak daun tanaman ketepeng (Cassia alata L) dalam menghambat pertumbuhan bakteri Ralstonia solanacearum dan Streptococcus sobrinus. ULIN: Jurnal Hutan Tropis, 3(1), 25–31. https://doi.org/10.32522/ujht.v3i1.2059
Eugresya, G., Avanti, C., & Uly, S. A. (2017). Pengembangan formula dan uji stabilitas fisik-pH sediaan gel facial wash yang mengandung ekstrak etanol kulit kayu kesambi. MPI (Media Pharmaceutica Indonesiana), 1(4), 181–188. https://doi.org/10.24123/mpi.v1i4.769
Falahi, A., Azizah, S. N., Indriani, E., & Indah, C. (2020). Pengaruh Propilen glikol dan Menthol sebagai enhancer terhadap sifat dan stabilitas fisik serta efektifitas anti inflamasi emulgel meloksikam. Journal Of Current Pharmaceutical Sciences, 3(2), 219–223.
Fitriani, I. R., & Nuryanti, S. (2023). Aktivitas antibakteri ekstrak etanol daun ketepeng cina ( Cassia alata L . ) Terhadap beberapa bakteri penyebab infeksi kulit. Makassar Natural Product Journal, 1(4), 22–28.
Gunarti, N. S. (2018). Pemanfaatan ekstrak daun jambu biji (Psidium guazava) sebagai gel facial wash antijerawat [Use of guava leaf extract. Pharma Xplore : Jurnal Ilmiah Farmasi, 3(2), 199–205. https://doi.org/10.36805/farmasi.v3i2.492
Hamni, L., Avidlyandi, Banon, C., Wiradimafan, K., Triawan, D., Wibowo, R., & Adfa, M. (2022). Kombinasi ekstrak metanol daun ketepeng cina (Cassia alata Linn.) dengan enam ekstrak tumbuhan terpilih dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Jurnal Pendidikan Biologi Dan Sains, 5(2), 350–362. https://doi.org/10.31539/bioedusains.v5i2.3996
Handayani, V. (2016). pengujian aktivitas antibakteri ekstrak etanol daun kersen (Muntingia calabura L.) terhadap bakteri penyebab jerawat. Jurnal Fitofarmaka Indonesia, 2(1), 94–96. https://doi.org/10.33096/jffi.v2i1.186
Hastuty, H. S. B., Purba, P. N., & Nurfadillah, E. (2018). Uji stabilitas fisik formulasi sediaan gel ekstrak daun ketepeng cina (Cassia alata l.) dengan gelling agent na cmc terhadap Staphylococcus aureus ATCC 230840. Jurnal Poltekkes Jayapura, 10(1), 22–27. https://doi.org/10.47539/gk.v10i1.5
Irianto, I. D. K., Purwanto, P., & Mardan, M. T. (2020). Aktivitas antibakteri dan uji sifat fisik sediaan gel dekokta sirih hijau (Piper betle L.) sebagai alternatif pengobatan mastitis sapi. Majalah Farmaseutik, 16(2), 202–210. https://doi.org/10.22146/farmaseutik.v16i2.53793
Juariah, S., Yolanda, N., & Surya, A. (2020). Efektivitas ekstrak etanol daun kersen terhadap Staphylococcus aureus dan Salmonella typhi. Jurnal Endurance : Kajian Ilmiah Problema Kesehatan, 5(2), 338–344. https://doi.org/10.22216/jen.v5i2.3140
Khaerati, K., & Ihwan. (2011). Uji efek antibakteri ekstrak etanol herba seledri (Apium graveolens Linn.) terhadap Escherichia coli dan Staphylococcus aureus dan analisis KLT bioautografi. Jurnal Biocelebes, 5(1), 13–21.
Kurniasari, F. (2016). Evaluasi uji hedonik dan uji iritasi sediaan lotion minyak atsiri daun cengkeh (Eugenia Aromatic L.). Jurnal Farmasi Indonesia, 13(2), 163–170. https://doi.org/10.31001/jfi.v13i2.287
Laras, A. A. I. S., Swastini, D. A., Wardana, M., & Wijayanti, N. P. A. D. (2014). Uji iritasi ekstrak etanol kulit buah manggis (Garcinia mangostana L.). Jurnal Farmasi Udayana, 3(1), 74–77.
Linda, R., Khotimah, S., & Elfiyanti. (2011). Aktivitas ekstrak daun ketepeng cina (Cassia alata Linn .) terhadap pertumbuhan jamur Cercospora personatum. Jurnal Biopropal Industri, 2(1), 1–7. https://doi.org/10.36974/jbi.v2i2.727
Ministry of Health RI. (2017). Farmakope herbal indonesia edisi II. Jakarta: Ministry of Health RI.
Nirmala, F. M., Saputri, G. A. R., & Marcellia, S. (2021). Formulasi sediaan facial wash kombinasi perasan jeruk lemon (Citrus Limon (L.)) dan ekstrak buah tomat (Solanum Lycopersicum L.) terhadap daya hambat bakteri Propionibacterium Acnes. Jurnal Mandala Pharmacon Indonesia, 7(2), 188–206. https://doi.org/10.35311/jmpi.v7i2.87
Nurlansi, & Jahidin. (2018). Uji aktivitas antibakteri ekstrak metanol dan fraksi etil asetat daun ketepeng cina (Casia alata L.). Indonesia Natural Research Pharmaceutical Journal, 2(2), 13–18. https://doi.org/10.52447/inspj.v2i2.780
Putri, L. E., Kamal, S., & Alhabil, L. (2022). Formulasi dan uji aktivitas antibakteri sediaan sabun transparan ekstrak gambir terpurifikasi kombinasi vco terhadap bakteri Propionibacterium Acnes. Jurnal Hasil Penelitian Dan Pengkajian Ilmiah Eksakta, 1(2), 80–88. https://doi.org/10.47233/jppie.v1i2.476
Putri, W. A. D. (2021). Formulasi sediaan facial wash ekstrak etanol daun kemangi (Ocimum basilicum L). [Thesis]. Malang: Universitas Islam Negeri Maulana Malik Ibrahim.
Rezali, Tandi, J., & Anggi, V. (2018). Daya hambat ekstrak terpurifikasi daun ketepeng terhadap bakteri Escherichia coli dan Staphylococcus aureus. Farmakologika Jurnal Farmasi, 15(2), 151–159.
Rifkowaty, E. E., & Fitriarni, D. (2020). Pengaruh konsentrasi sukrosa dan gliserin terhadap sabun transparan daun ketepeng (Cassia alata). Jurnal PATANI: Pengembangan Teknologi Pertanian Dan Informatika, 4(2), 6–11. https://doi.org/10.47767/patani.v4i2.83
Sarlina, S., Razak, A. R., & Tandah, M. R. (2017). Uji aktivitas antibakteri sediaan gel ekstrak daun sereh (Cymbopogon nardus L. Rendle) terhadap bakteri Staphylococcus aureus penyebab jerawat. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 3(2), 143–149. https://doi.org/10.22487/j24428744.0.v0.i0.8770
Sayuti, N. A. (2015). Formulasi dan uji stabilitas fisik sediaan gel ekstrak daun ketepeng cina (Cassia alata L.). Jurnal Kefarmasian Indonesia, 5(2), 74–82.
Setiawati, I., & Ariani, A. (2020). Kajian pH dan kadar air dalam SNI sabun mandi padat di Jabedebog. Pertemuan Dan Presentasi Ilmiah Standardisasi, 1(1), 293–300.
Singh, H. P., Samnhotra, N., Gullaiya, S., & Kaur, I. (2015). Anti-acne Synergistic Herbal Face Wash Gel: Formulation, Evaluation and Stability Studies. World Journal of Pharmaceutical Research, 4(9), 1261–1273.
Sumiati, T., Masaenah, E., & Mustofa, K. N. (2021). Formulasi obat kumur herbal ekstrak etanol kulit nanas (Ananas comosus (L.) Merr.) sebagai antibakteri Streptococcus sanguinis penyebab plak gigi. Jurnal Farmamedika (Pharmamedica Journal), 6(1), 15–23. https://doi.org/10.47219/ath.v6i1.112
Tsabitah, A. F., Zulkarnain, A. K., Wahyuningsih, M. S. H., & Nugrahaningsih, D. A. A. (2020). Optimasi carbomer, propilen glikol, dan trietanolamin dalam formulasi sediaan gel ekstrak etanol daun kembang bulan (Tithonia diversifolia). Majalah Farmaseutik, 16(2), 111–118. https://doi.org/10.22146/farmaseutik.v16i2.45666
Utami, N. F., Nurmala, S., Zaddana, C., & Rahmah, R. A. (2019). Uji aktivitas antibakteri sediaan face wash gel lendir bekicot (Archatina fulica) dan kopi robusta (Coffea canephora) terhadap bakteri Staphylococcus aureus. Jurnal Fitofarmaka, 9(1), 64–76. https://doi.org/10.33751/jf.v9i1.1262
Utomo, S. B., Fujiyanti, M., Lestari, W. P., & Mulyani, S. (2018). Uji aktivitas antibakteri senyawa C-4 metoksifenilkaliks [4]resorsinarena termodifikasi hexadecyltrimethylammonium-bromide terhadap bakteri Staphylococcus aureus dan Escherichia coli. JKPK (Jurnal Kimia Dan Pendidikan Kimia), 3(3), 201–209. https://doi.org/10.20961/jkpk.v3i3.22742
Wahyuni, S., Taufik, L., & Mustariani, B. A. A. (2021). Uji karakteristik sediaan masker gel peel-off berbahan dasar ekstrak daun kelor (Moringa oleifera) dan madu hutan terhadap kualitas kulit wajah. SPIN: Jurnal Kimia & Pendidikan Kimia, 3(2), 165–176. https://doi.org/10.20414/spin.v3i2.3909
Wardani, H. N. (2020). Potensi ekstrak daun sirsak dalam mengatasi kulit wajah berjerawat. Jurnal Penelitian Perawat Profesional, 2(4), 563–570. https://doi.org/10.37287/jppp.v2i4.218
Yuniarsih, N., Akbar, F., Lenterani, I., & Farhamzah. (2020). Formulasi dan evaluasi sifat fisik facial wash gel ekstrak kulit buah naga merah (Hylocereus polyrhizus) dengan gelling agent carbopol. Pharma Xplore : Jurnal Ilmiah Farmasi, 5(2), 57–67. https://doi.org/10.36805/jpx.v5i2.1194
Yusriana, C. S., Budi, C. S., & Dewi, T. (2014). Uji Daya hambat infusa daun nangka (Artocarpus heterophyllus) terhadap pertumbuhan bakteri Staphylococcus aureus. Jurnal Permata Indonesia, 5(2), 1–7.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Jurnal Kesehatan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.