Sunscreen Effect of Andaliman Methanol Extract Nano Gel on The Amount of Melanin in Wistar Rats Exposed to UV-B Light
DOI:
https://doi.org/10.26630/jk.v15i3.4486Keywords:
Andaliman extract, Radiation, UV-B exposure.Abstract
Excessive exposure to UV-B rays can increase melanin production, potentially causing skin damage, making it necessary to prevent this through the use of natural-based sunscreens, such as nano gel from methanol extract of andaliman, to protect the skin from the harmful effects of UV-B radiation. This study aims to evaluate the sunscreen effect of andaliman methanol extract nanogel on the amount of melanin in Wistar rats exposed to UV-B light. The method used was a laboratory experimental study with a randomized posttest only with a control group design using mice as the research subjects. The results of the study showed that the SPF values of andaliman extract at concentrations of 2%, 3.5%, and 5% were 2.11, 2.49, and 2.45, respectively, which are considered low for sunscreen protection standards. Additionally, the amount of melanin obtained from each treatment group was also categorized as small, indicating that the andaliman extract in nano gel form did not significantly reduce melanin production in Wistar rats exposed to UV-B rays. In conclusion, there is no sunscreen effect of andaliman methanol extract nanogel on the amount of melanin in Wistar rats exposed to UV-B light. This could be due to factors such as the low SPF value, the lack of stability of the active ingredients in the nano gel, or the need for an increased dosage. The implications of these findings suggest the need for further research to optimize the formulation or explore other more effective ingredients in preventing melanin production caused by UV-B exposure.
References
Ariani, L. W. (2020). Formulasi Dan Stabilitas Fisik Sediaan Nanogel Minyak Biji Matahari. REPOSITORY STIFAR.
Azmi, A. S. (2020). Kosmeseutikal Herbal Pada Hiperpigmentasi Pascainflamasi (Hpi). Gema Kesehatan, 12(2), 44–56.
Chellapa, P. et al. (2015). Nanoemulsion and Nanoemulgel as a Topical Formulation. IOSR J. Pharm. 5(10): 43–7. 6.
Ginting, L. E. B., Kotsasi, F., Chiuman, L., Nadapdap, T., Liena, L., & Pardianto, G. (2023). Efektivitas antimikroba ekstrak buah andaliman terhadap bakteri Klebsiella pneumoniae. Buletin Kedokteran & Kesehatan Prima, 2(2), 27-31. https://jurnal.unprimdn.ac.id/index.php/bulkesprima/article/view/4701
Handayani, L., Septiani, G., Putra, D. A. W., Aina, N., Darweni, S., & Rio, A. (2023). An Exploration of Phytochemical Content in The Endemic Flora of Seruyan District, Central Kalimantan. JST (Jurnal Sains Dan Teknologi), 12(3). https://doi.org/10.23887/jstundiksha.v12i3.68062
Hanum, T. I., & Laila, L. (2018). Evaluation of the anti-aging and anti-acne effect of Andaliman (Zanthoxylum acanthopodium DC.) ethanolic extract peel-off gel mask. Asian Journal of Pharmaceutical and Clinical Research, 11(13), 90.
Harahap, E. S., Ginting, C. N., Lubis, Y. M., & Chiuman, L. (2022). The Activity of Strawberry Extract as Sunscreen on Guinea Pigs Exposed to Sunlight. IOP Conference Series: Earth and Environmental Science, 1083(1), 012007. https://doi.org/10.1088/1755-1315/1083/1/012007
IH, S. F., Lintong, P. M., & Loho, L. L. (2015). Pengaruh pemberian umbi bengkuang (Pachyrrhizus erosus l urban) terhadap jumlah pigmen melanin kulit mencit (Mus musculus) yang dipaparkan sinar matahari. EBiomedik, 3(1). https://doi.org/10.35790/ebm.v3i1.6641
Ikalinus, R., Widyastuti, S. K., & Setiasih, N. L. E. (2015). Skrining fitokimia ekstrak etanol kulit batang kelor (Moringa oleifera). Indonesia Medicus Veterinus, 4(1), 71–79.
Imanto, T., Prasetiawan, R., & Wikantyasning, E. R. (2019). Formulasi dan karakterisasi sediaan nanoemulgel serbuk lidah buaya (Aloe vera L.). Pharmacon: Jurnal Farmasi Indonesia, 16(1), 28-37. https://journals.ums.ac.id/index.php/pharmacon/article/view/8114
Lamusu, D. (2018). Uji organoleptik jalangkote ubi jalar ungu (ipomoea batatas l) sebagai upaya diversifikasi pangan. Jurnal Pengolahan Pangan, 3(1), 9–15. https://doi.org/10.31970/pangan.v3i1.7
Layuck, A. R. P., Lintong, P. M., & Loho, L. L. (2015). Pengaruh pemberian air perasan jeruk nipis (Citrus aurantifolia) terhadap jumlah pigmen melanin kulit mencit (Mus musculus) yang dipaparkan sinar matahari. EBiomedik, 3(1). https://doi.org/10.35790/ebm.v3i1.6613
Lisnawati, N., NU, M. F., & Nurlitasari, D. (2019). Penentuan Nilai Spf Ekstrak Etil Asetat Daun Mangga Gedong Menggunakan Spektrofotometri Uv-Vis. Jurnal Riset Kefarmasian Indonesia, 1(2), 157–165. https://doi.org/10.33759/jrki.v1i2.35
Liu, W., Chen, Q., & Xia, Y. (2023). New mechanistic insights of melasma. Clinical, Cosmetic and Investigational Dermatology, pp. 429–442. https://www.tandfonline.com/doi/full/10.2147/CCID.S396272
Maan, A. A., Nazir, A., Khan, M. K. I., Ahmad, T., Zia, R., Murid, M., & Abrar, M. (2018). The therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, 12, 1-10. https://doi.org/10.1016/j.hermed.2018.01.002
Mohamed, M. B. M. (2020). Oily in situ gels as an alternative floating platform for ketoconazole release. International Journal of Research in Pharmaceutical Sciences, 11(2), 2638-2649. https://doi.org/10.26452/ijrps.v11i2.2278
Novianti, T., Zainuri, M., & Widowati, I. (2019). Aktivitas antioksidan dan identifikasi golongan senyawa aktif ekstrak kasar mikroalga chlorella vulgaris yang dikultivasi berdasarkan sumber cahaya yang berbeda. Barakuda’45, 1(2), 72–87. https://doi.org/10.47685/barakuda45.v1i2.44
Nurlaeni, Y., & Pratiwi, R. A. (2022a). Andaliman (Zanthoxylum Acanthopodium Dc.) Tumbuhan Rempah Sumatera Utara: Pemanfaatan Dan Potensi. Prosiding Seminar Nasional, 345–356.
Oktafianti, R., Soewondo, B. P., & Aryani, R. (2021). Kajian Pustaka Pemutih Kulit dari Bahan Alam serta Formulasinya dalam Sediaan Nanoemulsi. Prosiding Farmasi, 573–578.
Purwandari, V., Sianipar, A. Y., Silalahi, Y. C. E., & Nasution, D. J. (2020). Uji Efektivitas Antibakteri Nano Gel Bahan Aktif Ekstrak Kayu Manis (Cinnamomum burmannii) Terhadap Staphylococcus aureus. Jurnal Farmanesia, 7(2), 92–99. https://doi.org/10.51544/jf.v7i2.2776
Sari, W., Chiuman, L., Ginting, S. F., & Ginting, C. N. (2020). Pengaruh Krim Ekstrak Jintan Hitam (Nigella Sativa) Terhadap Kadar Kolagen Dan Hidrasi Kulit Pada Tikus (Rattus Norvegicus) Galur Wistar Jantan Yang Dipapar Sinar Ultraviolet-B. Berita Biologi, 19(3A), 321–325. https://doi.org/10.14203/beritabiologi.v19i3A.3863
Tamara, A., Harjanti, R., & Nilawati, A. (2020). Evaluasi Aktivitas Tabir Surya Krim Ekstrak Etanol Buah Tomat (Solanum lycopersicum L.) Secara in Vitro dan in Vivo. Prosiding Seminar Nasional Unimus.
Yadav, E., Kumar, S., Mahant, S., Khatkar, S., & Rao, R. (2017). Tea tree oil: a promising essential oil. Journal of Essential Oil Research, 29(3), 201-213. https://doi.org/10.1080/10412905.2016.1232665
Yonathan, K. H., Lintong, P. M., & Durry, M. F. (2016). Pengaruh pemberian ekstrak biji kakao (Theobroma cacao) terhadap jumlah pigmen melanin kulit tikus Wistar (Rattus novergicus) yang dipapar sinar matahari. EBiomedik, 4(2). https://doi.org/10.35790/ebm.v4i2.14710
Yuliawati, K. M., Sadiyah, E. R., Solehati, R., & Elgiawan, A. (2019). Sunscreen activity testing of robusta coffee (Coffea cenephora ex Froehner) leaves extract and fractions. Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 24–29.
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