Antidiabetic Effect of Noni Fruit and Moringa Leaves Extract on Blood Glucose Level, Hepatic and Pancreatic Histological Features of Diabetic Mice
DOI:
https://doi.org/10.26630/jk.v14i1.3619Keywords:
Blood glucose, Diabetes mellitus, Noni extract, Moringa leaves, Tissue histology.Abstract
One of the chronic diseases with high blood glucose levels is a characteristic of Diabetes Mellitus. Utilization of herbal ingredients needs to be developed to reduce blood sugar levels in diabetes, and one of them is by using moringa leaf extract and noni fruit. This study aimed to analyze the effect of a combination of moringa leaf extract and noni fruit on blood glucose levels and tissue cytology in diabetic mice. The study was a randomized pretest-posttest control group design using 28 male mice divided into seven groups. The data analysis showed the lowest decrease in blood glucose levels in the group of diabetic mice given noni fruit and moringa leaf extract at a dose of 150mg/20g BW/oral/day for two weeks. The results of histological examination of liver and pancreas tissue showed no tissue is damaged.References
Age, Age, SP (2021). The Effect of Giving Moringa Leaf Decoction on Decreased Blood Glucose Levels in Diabetes Mellitus. Journal of Health & Science: Gorontalo Journal of Health and Science Community, 5(2), 252–257. https://doi.org/10.35971/gojhes.v5i2.10383
Arwani, M. (2018). Produksi Tepung Daun Kelor (Moringa Oleifera) Rendah Saponin. [Thesis]. Malang: Fakultas Teknologi Pertanian, Universitas Brawijaya).
Brunetti, A., & Aversa, A. (2022). Editorial overview:‘Caring for diabetes in its complexity: From targetable metabolic-organ crosstalk to novel drug interactions. Curr. Opin. Pharmacol, 63, 102185. https://doi.org/10.1016/j.coph.2022.102185
Defirson & Azizah, L. (2021). Comparison of the effectiveness of oral antidiabetic drugs in type 2 diabetes mellitus outpatients at "X" Hospital, Jambi City. Health Information Research, 10 (2), 134–142. https://doi.org/10.30644/rik.v10i2.550
El Barky, A. R., Hussein, S. A., Alm-Eldeen, A. E., Hafez, Y. A., & Mohamed, T. M. (2017). Saponins and their potential role in diabetes mellitus. Diabetes Manag, 7(1), 148–58.
Ghorbani, A., Rashidi, R., & Shafiee-Nick, R. (2019). Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review. Biomedicine & Pharmacotherapy, pp. 111, 947-957. https://doi.org/10.1016/j.biopha.2018.12.127
Hardani, R., Krisna, I. K. A., Hamzah, B., & Hardani, M. F. (2020). Uji Anti Jamur Ekstrak Buah Mengkudu (Morinda citrifolia L.). Jurnal IPA & Pembelajaran IPA, 4(1), 92–102. https://doi.org/10.24815/jipi.v4i1.16579
Jusnita, N., & Syurya, W. (2019). Karakterisasi Nanoemulsi Ekstrak Daun Kelor (Moringa oleifera Lamk.) (Characterization of Nanoemulsion from Moringa oleifera’ Extract). Jurnal Sains Farmasi & Klinis, 6(1), 16–24. http://dx.doi.org/10.25077/jsfk.6.1.16-24.2019
Kononenko, NM, Ruban, OA, Chikitkina, VV, & Kovalevska, IV (2020). The influence of the antidiabetic combined medicinal product glycerin based on voglibose and quercetin on lipid exchange indications under conditions of experimental metabolic syndrome. Problems Endokrin Noi Pathology, 74 (4), 124–130. https://doi.org/10.21856/j-PEP.2020.4.16
Kusuma, IY, Samodra, G., Komala, YI, Puspita, E., Piri, JPA, Fauqina, A. . (2022). Glucose Lowering Agent Effect Dapagliflozin Adds On Metformin Therapy In Mice. Maritime Pharmacopoeia Scientific Journal, 72–80. https://journal.uniga.ac.id/index.php/JFB/article/download/1167/1089
Saputra, NT, Suartha, IN, & Dharmayudha, AAGO (2018). Streptozotocin Diabetogenic Agent for Making Male White Rats Diabetes Mellitus. Udayana Veterinary Bulletin , 10 (2), 116. https://doi.org/10.24843/bulvet.2018.v10.i02.p02
Syamra, A., & Indrawati, A. (2018). Pemberian Rebusan Daun Kelor Terhadap Penurunan Kadar Glukosa Darah Pada Pasien Penderita Diabetes Mellitus (DM). Jurnal Media Laboran, 8(2), 50-55. https://uit.e-journal.id/MedLAb/article/view/464
Widiastuti, TC, Khuluq, H., Handayani, EW, Wulandari, AS, & Hemas, E. (2022). Utilization of Medicinal Plants to Overcome Diabetes Mellitus in Kebumen City The Utilization of Diabetes Mellitus Medicinal Plants In Kebumen City. Journal of Clinical Pharmacy And Science (JFKS), 2 (1), 87–96.
Wulandari A., & Lakiu, DR (2022). Effect Test of noni leaf extract on decreasing blood glucose of white rats induced by streptozotocin. Pharmacology Journal of Pharmacy, 19 (1), 1–13.
Yanifa N., Syamsurizal, S., & Des, M. (2021). Inventory of Medicinal Plants with Antidiabetic Potential in IV Koto District, Agam Regency Inventory of Medicinal Plants with Antidiabetic Potential in Kecamaran IV Koto, Agam Regency. Biology Porch, 6 (1), 33–39. http://ejournal.unp.ac.id/students/index.php/bio/article/download/11717/4795
Downloads
Published
Issue
Section
License
Authors who publish in this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
