Scoping Review: Dampak Penggunaan Kontrasepsi Hormonal Memengaruhi Disfungsi Seksual Pada Wanita

Authors

  • Nelli Yendena Universitas Aisyiyah Yogyakarta
  • Mochamad Anwar Universitas Gadjah Mada
  • Farida Kartini Universitas Aisyiyah Yogyakarta
  • Andari Wuri Astuti Universitas Aisyiyah Yogyakarta

DOI:

https://doi.org/10.26630/jk.v14i1.3550

Keywords:

Contaceptive, Hormonal, Sexual dysfunction, Sexual function, Women.

Abstract

Hormonal contraception is very effective in preventing pregnancy, but this contraception has various side effects. The objective is to determine how hormonal contraceptive use affects sexual dysfunction in women. In this research, the author follows the Arksey and O'Malley framework by identifying questions, identifying relevant articles, selecting and selecting papers, mapping data, discussing, concluding, and reporting results. The prism flowchart displays the flow of article searches on four databases: PubMed, Wiley, EBSCO, and ProQuest. This Scoping Review found 14 articles out of 1441 selected based on inclusion and exclusion criteria into three themes. Hormonal changes due to using Combined Hormonal Contraceptive (CHC) contraception negatively affect sexual life, namely increasing Sex Hormone Binding Globulin (SHBG) and decreasing free testosterone. The effect of hormonal contraceptives on female sexual dysfunction decreases libido, pleasure, orgasm, difficulty in lubrication, and vaginal dryness. Other factors affecting women's sexual function include age, education, premenopause, marital status, consumption of antidepressants, differences in partner age, income, and household harmony. CHC hormonal contraceptives cause sexual dysfunction in women due to decreased androgen hormones in the ovaries.

References

Adeniji, A. A., Essah, P. A., Nestler, J. E., & Cheang, K. I. (2016). Metabolic effects of a commonly used combined hormonal oral contraceptive in women with and without polycystic ovary syndrome. Journal of women's health, 25(6), 638-645. https://doi.org/10.1089/jwh.2015.5418

Arksey, H., & O'Malley, L. (2005). Scoping studies: towards a methodological framework. International journal of social research methodology, 8(1), 19-32. https://doi.org/10.1080/1364557032000119616

Badan Penelitian dan Pengembangan Kesehatan. (2019). Laporan Nasional Riskesdas 2018. Lembaga Penerbit Balitbangkes.

Bahamondes, L., & Bahamondes, M. V. (2014). New and emerging contraceptives: a state-of-the-art review. International journal of women's health, 221-234. https://doi.org/10.2147/IJWH.S46811

Battaglia, C., Morotti, E., Persico, N., Battaglia, B., Busacchi, P., Casadio, P., . . . Venturoli, S. (2014). Clitoral vascularization and sexual behavior in young patients treated with drospirenone–ethinyl estradiol or contraceptive vaginal ring: a prospective, randomized, pilot study. The journal of sexual medicine, 11(2), 471-480. https://doi.org/10.1111/jsm.12392

Boozalis, M. A., Tutlam, N. T., Robbins, C. C., & Peipert, J. F. (2016). Sexual desire and hormonal contraception. Obstetrics and gynecology, 127(3), 563. https://doi.org/10.1097%2FAOG.0000000000001286

Burrows, L. J., Basha, M., & Goldstein, A. T. (2012). The effects of hormonal contraceptives on female sexuality: a review. The journal of sexual medicine, 9(9), 2213-2223. https://doi.org/10.1111/j.1743-6109.2012.02848.x

Butt, M. R., Lema, V., Mukaindo, A., Mohamoud, G., & Shabani, J. (2019). Prevalence of and factors associated with female sexual dysfunction among women using hormonal and non-hormonal contraception at the AGA Khan University Hospital Nairobi. African Journal of Primary Health Care & Family Medicine, 11(1), 1-9. http://dx.doi.org/10.4102/phcfm.v11i1.1955

Casey, P. M., MacLaughlin, K. L., & Faubion, S. S. (2017). Impact of contraception on female sexual function. Journal of women's health, 26(3), 207-213. https://doi.org/10.1089/jwh.2015.5703

ÄŒiaplinskienÄ—, L., ŽilaitienÄ—, B., VerkauskienÄ—, R., ŽalinkeviÄius, R., BumbulienÄ—, Ž., VanagienÄ—, V., & Bitzer, J. (2016). The effect of a drospirenone-containing combined oral contraceptive on female sexual function: a prospective randomised study. The European Journal of Contraception & Reproductive Health Care, 21(5), 395-400. https://doi.org/10.1080/13625187.2016.1217324

Curran, K. A. (2019). Case Report: Persistent genital arousal disorder in an adolescent woman. Journal of Pediatric and Adolescent Gynecology, 32(2), 186-188. https://doi.org/10.1016/j.jpag.2018.11.009

de Castro Coelho, F., & Barros, C. (2019). The potential of hormonal contraception to influence female sexuality. International journal of reproductive medicine, Volume 2019. https://doi.org/10.1155/2019/9701384

Di Carlo, C., Sansone, A., De Rosa, N., Gargano, V., Tommaselli, G. A., Nappi, C., & Bifulco, G. (2014). Impact of an implantable steroid contraceptive (etonogestrel-releasing implant) on quality of life and sexual function: a preliminary study. Gynecological Endocrinology, 30(1), 53-56. https://doi.org/10.3109/09513590.2013.848851

Enzlin, P., Weyers, S., Janssens, D., Poppe, W., Eelen, C., Pazmany, E., . . . Amy, J.-J. (2012). Sexual functioning in women using levonorgestrel-releasing intrauterine systems as compared to copper intrauterine devices. The journal of sexual medicine, 9(4), 1065-1073. https://doi.org/10.1111/j.1743-6109.2011.02266.x

Espitia De La Hoz, F. J., & Orozco Gallego, H. (2018). Alteration of the sexual response cycle in women using combined oral contraceptives. Revista Salud Uninorte, 34(2), 430-442. https://doi.org/10.14482/sun.34.2.613.94

Fataneh, G., Marjan, M. H., Nasrin, R., & Taraneh, T. (2013). Sexual function in I ranian women using different methods of contraception. Journal of Clinical Nursing, 22(21-22), 3016-3023. https://doi.org/10.1111/jocn.12289

Fatmawati, Z., Budihastuti, U. R., & Dewi, Y. L. R. (2017). The Effect of Combined Oral Contraceptives on Sexual Function among Women of Reproductive Age in Jombang District, East Java. Journal of Maternal and Child Health, 2(2), 100-112. https://doi.org/10.26911/thejmch.2017.02.02.02

Graziottin, A. (2016). The shorter, the better: A review of the evidence for a shorter contraceptive hormone-free interval. The European Journal of Contraception & Reproductive Health Care, 21(2), 93-105. https://doi.org/10.3109/13625187.2015.1077380

Grebe, N. M., Gangestad, S. W., Garver-Apgar, C. E., & Thornhill, R. (2013). Women’s luteal-phase sexual proceptivity and the functions of extended sexuality. Psychological science, 24(10), 2106-2110. https://doi.org/10.1177/0956797613485965

Grøntvedt, T. V., Grebe, N. M., Kennair, L. E. O., & Gangestad, S. W. (2017). Estrogenic and progestogenic effects of hormonal contraceptives in relation to sexual behavior: Insights into extended sexuality. Evolution and Human Behavior, 38(3), 283-292. https://doi.org/10.1016/j.evolhumbehav.2016.10.006

Hamadiyan, H., Oladi, M. A. G., Rahbar, P., & Azad, M. (2016). Prevalence of sexual dysfunction among women using contraceptive methods. International Journal of Medical Research & Health Sciences, 5(12), 163-167. https://www.indianjournals.com/ijor.aspx?target=ijor:ijmrhs&volume=5&issue=12&article=025

Hassanin, A. M., El-Halwagy, A. M., Ismail, N. N., & Shehab, B. A. (2018). A study of the impact of the commonly used female contraceptive methods in Egypt on female sexual function. Journal of Sex & Marital Therapy, 44(6), 605-612. https://doi.org/10.1080/0092623X.2018.1437579

Kariman, N., Sheikhan, Z., Simbar, M., Zahiroddin, A., & Akbarzadeh Bahgban, A. (2017). Sexual dysfunction in two types of hormonal contraception: combined oral contraceptives versus depot medroxyprogesterone acetate. Journal of Midwifery and Reproductive Health, 5(1), 806-813. https://doi.org/10.22038/jmrh.2016.7763

Keenan, L., Kerr, T., Duane, M., & Van Gundy, K. (2018). Systematic review of hormonal contraception and risk of venous thrombosis. The Linacre Quarterly, 85(4), 470-477. https://doi.org/10.1177/0024363918816683

Lee, J.-J. M., Low, L. L., & Ang, S. B. (2017). Oral contraception and female sexual dysfunction in reproductive women. Sexual Medicine Reviews, 5(1), 31-44. https://doi.org/10.1016/j.sxmr.2016.06.001

Lu, C. F., Vargas, S. E., Guillen, M., Ramirez, J. J., Carbone, S. L., Getz, M. L., . . . Tong, I. (2019). A qualitative study of the contraceptive effect on women’s sexual experiences: beyond hormonal effects. Obstetrics and gynecology, 134(1), 91. https://doi.org/10.1097%2FAOG.0000000000003331

Maita, L. (2016). Pengaruh pijat oksitosin terhadap produksi ASI. Jurnal Penelitian Kesehatan" SUARA FORIKES"(Journal of Health Research" Forikes Voice"), 7(3), 173-175. http://forikes-ejournal.com/index.php/SF/article/view/47

Malmborg, A., Brynte, L., Falk, G., Brynhildsen, J., Hammar, M., & Berterö, C. (2020). Sexual function changes attributed to hormonal contraception use–a qualitative study of women experiencing negative effects. The European Journal of Contraception & Reproductive Health Care, 25(3), 169-175. https://doi.org/10.1080/13625187.2020.1736545

Malmborg, A., Persson, E., Brynhildsen, J., & Hammar, M. (2015). Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women. The European Journal of Contraception & Reproductive Health Care, 21(2), 158-167. https://doi.org/10.3109/13625187.2015.1079609

Masters, N. T., Morrison, D. M., Querna, K., Casey, E. A., & Beadnell, B. (2017). Correlates of young men's intention to discuss birth control with female partners. Perspectives on sexual and reproductive health, 49(1), 37-43. https://doi.org/10.1363/psrh.12005

Montejo, A. L., Calama, J., Rico-Villademoros, F., Montejo, L., González-García, N., & Pérez, J. (2019). A real-world study on antidepressant-associated sexual dysfunction in 2144 outpatients: the SALSEX I study. Archives of sexual behavior, 48, 923-933. https://doi.org/10.1007/s10508-018-1365-6

Montejo, Ã. L., Majadas, S., Rico-Villademoros, F., LLorca, G., De La Gándara, J., Franco, M., . . . Dysfunction, S. W. G. f. t. S. o. P.-R. S. (2010). Frequency of sexual dysfunction in patients with a psychotic disorder receiving antipsychotics. The journal of sexual medicine, 7(10), 3404-3413. https://doi.org/10.1111/j.1743-6109.2010.01709.x

Moreira, I. F. d. A., Bianchini, M. P., Moreira, G. R. C., Almeida, A. M., & Rezende, B. A. (2020). Sexual function and metabolic/hormonal changes in women using long-term hormonal and non-hormonal contraceptives: a pilot study. BMC Women's Health, 20(1), 1-11. https://doi.org/10.1186/s12905-020-01107-1

Morotti, E., Casadio, P., Guasina, F., Battaglia, B., Mattioli, M., & Battaglia, C. (2017). Weight gain, body image and sexual function in young patients treated with contraceptive vaginal ring. A prospective pilot study. Gynecological Endocrinology, 33(8), 660-664. https://doi.org/10.1080/09513590.2017.1306850

Nimbi, F. M., Rossi, R., Tripodi, F., Wylie, K., & Simonelli, C. (2019). A biopsychosocial model for the counseling of hormonal contraceptives: A review of the psychological, relational, sexual, and cultural elements involved in the choice of contraceptive method. Sexual Medicine Reviews, 7(4), 587-596. https://doi.org/10.1016/j.sxmr.2019.06.005

Oindi, F. M., Murage, A., Lema, V. M., & Mukaindo, A. M. (2019). Association of female sexual dysfunction and fertility: a cross sectional study. Fertility research and practice, 5, 1-11. https://doi.org/10.1186/s40738-019-0065-9

Okigbo, C. C., Speizer, I. S., Domino, M. E., Curtis, S. L., Halpern, C. T., & Fotso, J. C. (2018). Gender norms and modern contraceptive use in urban Nigeria: a multilevel longitudinal study. BMC Women's Health, 18, 1-17. https://doi.org/10.1186/s12905-018-0664-3

Palacios, S., Regidor, P.-A., Colli, E., Skouby, S. O., Apter, D., Roemer, T., . . . Jakimiuk, A. J. (2020). Oestrogen-free oral contraception with a 4 mg drospirenone-only pill: new data and a review of the literature. The European Journal of Contraception & Reproductive Health Care, 25(3), 221-227. https://doi.org/10.1080/13625187.2020.1743828

Pastor, Z., Holla, K., & Chmel, R. (2013). The influence of combined oral contraceptives on female sexual desire: a systematic review. The European Journal of Contraception & Reproductive Health Care, 18(1), 27-43. https://doi.org/10.3109/13625187.2012.728643

Polis, C. B., Curtis, K. M., Hannaford, P. C., Phillips, S. J., Chipato, T., Kiarie, J. N., . . . Steyn, P. S. (2016). An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women. AIDS (London, England), 30(17), 2665. https://doi.org/10.1097%2FQAD.0000000000001228

Pyke, R. E., & Clayton, A. H. (2019). Lumping, splitting, and treating: therapies are needed for women with overlapping sexual dysfunctions. Sexual Medicine Reviews, 7(4), 551-558. https://doi.org/10.1016/j.sxmr.2019.04.002

Roney, J. R., & Simmons, Z. L. (2013). Hormonal predictors of sexual motivation in natural menstrual cycles. Hormones and behavior, 63(4), 636-645. https://doi.org/10.1016/j.yhbeh.2013.02.013

Sari, D. N. A., Suryati, S., Budiyati, G. A., Setyawan, A. S., & Hikmawati, A. N. (2021). Lama Penggunaan Kontrasepsi Hormonal Berhubungan Dengan Disfungsi Seksual. Jurnal Keperawatan, 13(1), 19-28. http://journal.stikeskendal.ac.id/index.php/Keperawatan/article/view/1080

Schaffir, J. A., Isley, M. M., & Woodward, M. (2010). Oral contraceptives vs injectable progestin in their effect on sexual behavior. American journal of obstetrics and gynecology, 203(6), 545. e541-545. e545. https://doi.org/10.1016/j.ajog.2010.07.024

Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016). Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face. Social Cognitive and Affective Neuroscience, 11(5), 767-774. https://doi.org/10.1093/scan/nsv157

Smith, N. K., Jozkowski, K. N., & Sanders, S. A. (2014). Hormonal contraception and female pain, orgasm and sexual pleasure. The journal of sexual medicine, 11(2), 462-470. https://doi.org/10.1111/jsm.12409

Sobecki, J. N., Curlin, F. A., Rasinski, K. A., & Lindau, S. T. (2012). What we don’t talk about when we don’t talk about sex1: Results of a national survey of US obstetrician/gynecologists. The journal of sexual medicine, 9(5), 1285-1294. https://doi.org/10.1111/j.1743-6109.2012.02702.x

Strufaldi, R., Pompei, L. M., Steiner, M. L., Cunha, E. P., Ferreira, J. A., Peixoto, S., & Fernandes, C. E. (2010). Effects of two combined hormonal contraceptives with the same composition and different doses on female sexual function and plasma androgen levels. Contraception, 82(2), 147-154. https://doi.org/10.1016/j.contraception.2010.02.016

Wang, Q., Würtz, P., Auro, K., Morin-Papunen, L., Kangas, A. J., Soininen, P., . . . Havulinna, A. S. (2016). Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. International Journal of Epidemiology, 45(5), 1445-1457. https://doi.org/10.1093/ije/dyw147

World Health Organization. (2018). Family planning: a global handbook for providers: evidence-based guidance developed through worldwide collaboration. USAID, World Health Organization.

Yendena, N., Kurniawati, H. F., & Jannatul, H. (2020). Men's Participation in Family Planning. International Journal of Advanced Science and Technology, 29(7), 573 - 583. http://sersc.org/journals/index.php/IJAST/article/view/13329

Yendena, N., Mawarti, R., & Husna, J. (2022). Pengaruh Penyuluhan KB dalam Pandangan Islam terhadap Keikutsertaan Pemilihan Kontrasepsi bagi Calon Akseptor di Dusun Jabung Yogyakarta Indonesia. Jurnal Genta Kebidanan, 12(1), 1-6. https://doi.org/10.36049/jgk.v12i1.66

Yosin, E. P., Mudigdo, A., & Budihastuti, U. R. (2016). Effect of Hormonal Contraceptive on Sexual Life, Body Mass Index, Skin Health, and Uterine Bleeding, in Women of Reproduction Age in Jombang, East Java. Journal of Maternal and Child Health, 1(3), 146-160. https://doi.org/10.26911/thejmch.2016.01.03.02

Zettira, Z., & Berawi, K. N. (2015). Analisis hubungan penggunaan kontrasepsi hormonal dengan disfungsi seksual pada wanita. Jurnal Majority, 4(7), 103-108. https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/1457

Downloads

Published

30-04-2023

Issue

Vol. 14 No. 1 (2023): Jurnal Kesehatan

Section

Articles

License

Authors who publish in this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.