The Rationality of Drug Use in GERD Patients at The Outpatient Installation of RSUD Dr. Soedarso Pontianak
DOI:
https://doi.org/10.26630/jk.v14i1.3530Keywords:
Comorbidities, GERD, Rationality, Types of drugs.Abstract
Gastroesophageal Reflux Disease (GERD) prevalence has increased from 2016 to 2018 by 21,6%. Inappropriate indication, drug, dose, route of administration, and time interval of administration could lead to therapeutic failure. This study aimed to evaluate the rationality of drug use and the distribution of drug use patterns in GERD patients at the outpatient installation of RSUD Dr. Soedarso Pontianak. This research method is descriptive and observational with a cross-sectional design. Data collection was delivered retrospectively with medical records data and prescriptions of GERD patients during the 2020-2021 period. The sampling technique used is purposive sampling, where the sample selection is based on the specified inclusion criteria. The sample used in the study was 98 patients. The results showed that the percentage of rationality in patients without comorbidities was based on 100% correct indication, 93,85% correct drug, 100% correct dose, 100% valid route of administration, and 100% accurate time interval for administration and with comorbidities based on proper indication 87,88%, 57,58% correct drug, 100% correct dose, 100% correct route of administration, and 100% accurate time interval for administration. Distribution pattern of GERD drug use in GERD patients without/with comorbidities was the most widely used is Lansoprazole (monotherapy). The most commonly used is a Proton Pump Inhibitor (PPI) with sucralfate for the benefit of combination drugs.References
American Pharmacists Association. (2012). Drug Information Handbook 21st Edition. Ohio: Lexicomp.
Amrulloh, F. M., & Utami, N. (2016). Hubungan konsumsi OAINS terhadap gastritis. Jurnal Majority, 5(5), 18-21. https://juke.kedokteran.unila.ac.id/index.php/majority/article/view/917
Andrew, M., & John, L. (2020). Management of Hemorrhoids: Current Surgical Therapy 13th Edition Book https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hemorrhoid
Antunes, C., Aleem, A., & Curtis, S. A. (2017). Gastroesophageal reflux disease. In: StatPearls. StatPearls Publishing, Treasure Island (FL). https://europepmc.org/article/NBK/nbk441938
Ariska, R. (2021). Mengenal Gastroesophageal Reflux Disease (GERD). https://radioedukasi.kemdikbud.go.id/read/2849/mengenal-gastroesophageal-reflux-disease-gerd.html
Astuti, S. D., Lubis, N. D., & Kurniasari, F. (2017). Evaluasi Ketidaktepatan Pemilihan Obat Berdasarkan Kriteria STOPP Pada Pasien Geriatri. Jurnal Farmasi Indonesia, 14(2), 182-190. https://doi.org/10.31001/jfi.v14i2.347
Badan Pengawas Obat dan Makanan (BPOM). (2021). Pusat Informasi Obat Nasional (PIONAS). Jakarta. http://pionas.pom.go.id/ioni/pedoman-umum
British National Formulary. (2017). British National Formulary 73rd Edition. Joint Formulary Committee.
Dewantara, F., Waleleng, B. J., & Umboh, O. (2018). Profil Gambaran Endoskopi di Pusat Endoskopi KSM Ilmu Penyakit Dalam RSUP Prof. Dr. RD Kandou Periode Januari 2016-Desember 2017. e-CliniC, 6(2). https://ejournal.unsrat.ac.id/v3/index.php/eclinic/article/view/22114
Dipiro, J., Yee, G., Haines, S., Nolin, T., & Ellingrod, V. (2020). Pharmacotherapy: a pathophysiologic approach. 11th Edition. New York: McGraw-Hill Companies.
Fauziah, D. W. (2019). GAMBARAN PENGGUNAAN SUKRALFAT PADA PASIEN GASTRITIS RAWAT INAP PENYAKIT DALAM DI RS. HASANUDDIN DAMRAH BENGKULU. Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram, 5(1), 46-52. http://www.lppm.poltekmfh.ac.id/index.php/JPKIK/article/view/20
Friyanto, D., & Lestari, S. (2019). Analisis Penggunaan Obat Gastroesophageal Reflux Disease (GERD) Pada Pasien Rawat Jalan di Rumah Sakit Umum Daerah Karawang. Pharma Xplore: Jurnal Sains dan Ilmu Farmasi, 4(1), 240-247. https://doi.org/10.36805/farmasi.v4i1.614
Gunawan, D. F., Waleleng, B. J., & Polii, E. B. (2019). Profil pasien endoskopi gastrointestinal di RSUP Prof. Dr. RD Kandou periode Januari 2018-Agustus 2019. e-CliniC, 7(2). https://doi.org/10.35790/ecl.v7i2.26834
Heidelbaugh, J. J., Rew, K. T., & Harrison, R. V. (2013). Gastroesophageal Reflux Disease (GERD). UMHS GERD Guideline.
Jeong, E., Yoo, I. K., Yeniova, A. Ö., Yon, D. K., & Cho, J. Y. (2020). Confocal Laser Endomicroscopic Findings of Refractory Erosive Reflux Disease versus Non-Erosive Reflux Disease with Anti-Reflux Mucosectomy: An in vivo and ex vivo study. Clinical Endoscopy, 54(1), 55–63. https://doi.org/10.5946/ce.2020.040
Kaminang, G. A., Waleleng, B. J., & Polii, E. B. (2016). Profil Endoskopi Gastrointestinal di RSUP Prof. Dr. RD Kandou Manado periode Januari 2016–Agustus 2016. e-CliniC, 4(2). https://ejournal.unsrat.ac.id/index.php/eclinic/article/view/14562
Kementrian Kesehatan RI. (2011). Modul Penggunaan Obat Rasional,. Jakarta: Kementerian Kesehatan RI.
Li, Z.-t., Ji, F., Han, X.-w., Wang, L., Yue, Y.-q., & Wang, Z.-g. (2018). The role of gastroesophageal reflux in provoking high blood pressure episodes in patients with hypertension. Journal of clinical gastroenterology, 52(8), 685. https://doi.org/10.1097%2FMCG.0000000000000933
Mahdayana, I. D. (2020). Studi Penggunaan Profilaksis Stress Ulcer pada Pasien Bedah Digestif di RSUD dr. Soetomo Surabaya. Pharmaceutical Journal of Indonesia, 5(2), 73-78. https://doi.org/10.21776/ub.pji.2020.005.02.1
Mardhiyah, R., Fauzi, A., & Syam, A. F. (2015). Diagnosis dan Tata Laksana Enteropati akibat Obat Anti Inflamasi Non Steroid (OAINS). Jurnal Penyakit Dalam Indonesia, 2(3), 190-197. http://dx.doi.org/10.7454/jpdi.v2i3.84
Minatsuki, C., Yamamichi, N., Shimamoto, T., Kakimoto, H., Takahashi, Y., Fujishiro, M., . . . Matsuda, R. (2013). Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan. PloS one, 8(7), e69891. https://doi.org/10.1371/journal.pone.0069891
Mungan, Z., & Pinarbasi Simsek, B. (2017). Which drugs are risk factors for the development of gastroesophageal reflux disease?. The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology, 28(Suppl 1), S38-S43. https://doi.org/10.5152/tjg.2017.11
Ndraha, S., Oktavius, D., Fransisca, F., Sumampouw, J. L., Juli, N. N., & Marcel, R. (2016). Faktor-Faktor yang Berhubungan dengan Keberhasilan Terapi GERD. Jurnal Kedokteran Meditek, 22(60). http://ejournal.ukrida.ac.id/ojs/index.php/Meditek/article/view/1447
Patala, R., Tandi, J., Ulzmi, N., & Fahruddin, F. (2021). Rasionalitas Penggunanaan Obat Pada. Pasien GERD Di Instalasi Rawat Inap Rumah Sakit Umum Anutapura Palu. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 6(1), 62-73. https://doi.org/10.20961/jpscr.v6i1.43170
Permana, L. (2020). Peningkatan Perilaku Perawat Melalui Pengetahuan Dalam Menjalankan Prinsip Pemberian Obat Dua Belas Benar. Journal Of Health Science (Jurnal Ilmu Kesehatan), 5(2), 79-85. https://ejournalwiraraja.com/index.php/JIK/article/view/1126
Radjamin, I., Nusi, I. A., & Kalanjati, V. P. (2019). Profil penderita gastroesophageal reflux disease (GERD) dan non-erosive reflux disease (NERD) di RSUD Dr. Soetomo Surabaya. Majalah Biomorfologi, 29(1), 13-18. https://e-journal.unair.ac.id/MBIO/article/view/16111
Rahman, A. A., Maulidina, W., & Kosasih, E. D. (2019). TERAPI AWAL PADA PASIEN GERD (GASTROESOPHAGEAL REFLUX DISEASE) DI POLIKLINIK PENYAKIT DALAM RSUD dr. SOEKARDJO TAHUN 2018. JURNAL KESEHATAN POLTEKKES KEMENKES RI PANGKALPINANG, 6(2), 69-75. https://doi.org/10.32922/jkp.v6i2.81
Ramachandran, A. (2014). Know the signs and symptoms of diabetes—the Indian Journal of medical research, 140(5), 579. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311308/
Rositah, D. S. A., Diniarti, F. A., Octaviani, I., & Putri, N. (2022). Penyalahgunaan Obat Sedatif serta Dampak Pengguna terhadap Kesehatan dan Sosial: Literature Review. 2-TRIK: TUNAS-TUNAS RISET KESEHATAN, 12(1), 13-19. http://2trik.jurnalelektronik.com/index.php/2trik/article/view/2trik12103
Rustiasari, U. J., & Handjari, D. R. (2017). Histopathological diagnostic criteria of Barrett esophagus and its association with endoscopy findings. JKKI: Jurnal Kedokteran dan Kesehatan Indonesia, 45-57. https://doi.org/10.20885/JKKI.Vol8.Iss1.art7
Safitri, D., & Nurman, M. (2020). Pengaruh Konsumsi Perasan Air Kunyit Terhadap Rasa Nyeri Pada Penderita Gastritis Akut Usia 45-54 Tahun Di Desa Kampung Pinang Wilayah Kerja Puskesmas Perhentian Raja. Jurnal Ners, 4(2), 130-138. http://journal.universitaspahlawan.ac.id/index.php/ners/article/view/1147
Santika, N. Y., Desnita, R., & Yuswar, M. A. (2019). Evaluation of Peptic Ulcer Medication Use in Patients with Peptic Ulcer at Inpatient Installation RSUD Sultan Syarif Mohamad Alkadrie. Majalah Farmaseutik, 15(1), 1-15. https://doi.org/10.22146/farmaseutik.v15i1.45261
Sari, D. P. (2020). Evaluasi Penggunaan Obat Rasional di Puskesmas Kabupaten Pasuruan Tahun 2019 berdasarkan Indikator Pencapaian Kementerian Kesehatan. FARMASIS: Jurnal Sains Farmasi, 1(1), 1-5. https://jurnal.unipasby.ac.id/index.php/farmasis/article/view/2659
Sharma, V. K. (2014). Role of endoscopy in GERD. Gastroenterology Clinics, 43(1), 39–46. https://doi.org/10.1016/j.gtc.2013.12.003
Suherman, L., Ramdani, R., Septiani, V., Indrayani, W., Islamiyah, A. N., & Hasyim, P. (2021). POLA PENGGUNAAN OBAT PADA PASIEN GASTROESOPHAGEAL REFLUX DISEASE (GERD) DI SALAH SATU RUMAH SAKIT DI BANDUNG. Pharmacoscript, 4(2), 222-233. https://doi.org/10.36423/pharmacoscript.v4i2.713
Sulistyarini, I. (2013). Terapi relaksasi untuk menurunkan tekanan darah dan meningkatkan kualitas hidup penderita hipertensi. Jurnal Psikologi, 40(1), 28-38. https://journal.ugm.ac.id/jpsi/article/view/7064
Syam, A. F., Aulia, C., Renaldi, K., Simadibrata, M., Abdullah, M., & Tedjasaputra, T. R. (2013). Revisi konsensus nasional penatalaksanaan penyakit refluks gastroesophageal (gastroesophageal reflux disease/GERD) di Indonesia. Perkumpulan Gastroenterologi Indonesia, 263-270.
Syam, A. F., Hapsari, P. F., & Makmun, D. (2016). The prevalence and risk factors of GERD among Indonesian medical doctors. Makara Journal of Health Research, 35-40. https://doi.org/10.7454/msk.v20i2.5740
Tandi, J. (2017). Tinjauan Pola Pengobatan Gastritis Pada Pasien Rawat Inap RSUD Luwuk. PHARMACON, 6(3). https://ejournal.unsrat.ac.id/v3/index.php/pharmacon/article/view/17753
Tarigan, R., & Pratomo, B. (2019). Analisis faktor risiko gastroesofageal refluks di RSUD Saiful Anwar Malang. Jurnal Penyakit Dalam Indonesia, 6(2), 78-81.
Wardaniati, I., Almahdy, A., & Dahlan, A. (2017). Gambaran Terapi Kombinasi Ranitidin Dengan Sukralfat Dan Ranitidin Dengan Antasida Dalam Pengobatan Gastritis di SMF Penyakit Dalam Rumah Sakit Umum Daerah (RSUD) Ahmad Mochtar Bukittinggi. Jurnal Farmasi Higea, 8(1), 65-74. http://www.jurnalfarmasihigea.org/index.php/higea/article/view/139
Widayat, W., Ghassani, I. K., & Rijai, L. (2018). Profil Pengobatan Dan Drp’S Pada Pasien Ganguan Lambung (Dyspepsia, Gastritis, Peptic Ulcer) Di Rsud Samarinda. Jurnal Sains dan Kesehatan (J. Sains Kes.), 1(10), 539-547. https://doi.org/10.25026/jsk.v1i10.100
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