Pengaruh Ekstrak Etanol Daun Rhizophora apiculata terhadap Kolesterol Total dan Trigliserida Rattus norvegicus Galur Sprague dawley yang Diinduksi Diet Tinggi Lemak

Authors

  • Syazili Mustofa universitas Lampung
  • Farhan Kamali Adli Universitas Lampung
  • Dyah Wulan Sumekar Rengganis Wardani Universitas Lampung
  • Hendri Busman Universitas Lampung

DOI:

https://doi.org/10.26630/jk.v13i3.3178

Keywords:

Cholesterol total, Dyslipidemia, High fat diet, Rhizophora apiculata, Triglyceride.

Abstract

Dyslipidemia is a lipid metabolism disorder in the form of an increase and decrease in the lipid fraction which is one of the high-risk factors for coronary heart disease and other non-communicable diseases. Rhizophora apiculata contains secondary metabolites in the form of flavonoid, tannin, alkaloid, saponin, and terpenoid which are thought to have the effect of preventing an increase in total cholesterol and triglyceride. This research is an experimental study with a posttest-only control group design carried out for 30 days using 30 experimental animals of Rattus norvegicus Sprague Dawley. There were 6 treatment groups, KN which was only given standard feed, K+ which was given quail egg yolk induction, simvastatin 10 mg/day, and K- which was given quail egg yolk induction. On the other hand, P1, P2, and P3 were given quail egg yolk induction, respectively. and leaf extract of Rhizophora apiculata with doses of 56mg/KgBW,m28mg/KgBW, and 14mg/KgBW. Then the rats were terminated using ketamine xylazine and blood was taken through the heart to be examined for total cholesterol and triglyceride using spectrophotometry. The results of the normality Shapiro-Wilk and Levene test p-value>0.05. In the One-way Anova test, cholesterol levels were 0.006 and triglyceride 0,002 (p-value<0.05), which indicated that there were significant differences between groups. The results of the post hoc LSD test on total cholesterol K- were significantly different from P1 and P2 and triglyceride K- were significantly different from P1, P2, and P3 (p-value<0.05). The administration of Rhizophora apiculata leaf extract had the effect of preventing the increase in total cholesterol and triglyceride levels of rats fed a high-fat diet.

Author Biographies

Syazili Mustofa, universitas Lampung

Program Studi Pendidikan Dokter, Fakultas Kedokteran

Farhan Kamali Adli, Universitas Lampung

Program Studi Profesi Dokter, Fakultas Kedokteran

Dyah Wulan Sumekar Rengganis Wardani, Universitas Lampung

Bagian Ilmu Kedokteran Komunitas dan Ilmu Kesehatan Masyarakat, Fakultas Kedokteran

Hendri Busman, Universitas Lampung

Bagian Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam

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Published

13-12-2022

Issue

Vol. 13 No. 3 (2022): Jurnal Kesehatan

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