Hubungan Indeks Massa Tubuh dengan Keparahan dan Mortalitas Pasien Covid-19
DOI:
https://doi.org/10.26630/jk.v13i2.3051Keywords:
Body mass index, Covid-19, Mortality, Severity.Abstract
Covid-19 is a novel viral disease resulting in many casualties around the world, including in Indonesia. By the 19th of January 2022, the death rate is 3.36% higher than the world’s, i.e., 1.64%. Covid-19 -related death is caused by several factors; one of them is body mass index (BMI). A patient’s BMI affects the clinical condition as well as the severity of the case. Increasing BMI is believed to be a risk and mortality factor for Covid-19 patients. This research aimed at identifying the relationship between BMI and the severity as well as mortality of Covid-19 patients. From March 2020 to June 2021, as many as 345 in-patients at RSU Haji Surabaya were studied using the retrospective cohort research method. The data were analyzed using Chi-square with <0.05 significance value to see the relationship amongst its test variables. The results indicated that there was no significant relationship between body mass index and severity and mortality in Covid-19 patients. Therefore, it can be concluded that the severity and mortality of Covid-19 patients in Indonesia were not dependent only on the increase in BMI.ÂReferences
Adimara, A., Prahasanti, K., & Airlangga, M. P. (2021). Pengaruh Peningkatan Jaringan Adiposa pada Pasien Obesitas Terhadap Tingkat Keparahan Pasien Covid-19. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 10(2), 222-242. http://dx.doi.org/10.30742/jikw.v10i2.1453
Aqmarina, N. W., Risanti, E. D., Mahmudah, L. N. ., & Jatmiko, S. W. (2021). Obesitas Sebagai Faktor Risiko Keparahan Pada Covid-19. Proceeding of The URECOL, November 2020, 371-377. http://repository.urecol.org/index.php/proceeding/article/view/1422
Biswas, M., Rahaman, S., Biswas, T. K., Haque, Z., & Ibrahim, B. (2021). Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis. Intervirology, 64(1), 36-47. https://doi.org/10.1159/000512592
Bonanad, C., GarcÃa-blas, S., Tarazona-santabalbina, F., Sanchis, J., Bertomeu-gonzález, V., Fácila, L., Ariza, A., Núñez, J., & Cordero, A. (2020). The Effect of Age on Mortality in Patients With COVID-19 : A Meta-Analysis With 611 , 583 Subjects. Journal of the American Medical Directors Association, 21(7), 915-918. https://doi.org/10.1016/j.jamda.2020.05.045
Dalal, J., Triulzi, I., James, A., Nguimbis, B., Dri, G. G., Venkatasubramanian, A., Noubi Tchoupopnou Royd, L., Botero Mesa, S., Somerville, C., Turchetti, G., Stoll, B., Abbate, J. L., Mboussou, F., Impouma, B., Keiser, O., & Coelho, F. C. (2021). COVID-19 mortality in women and men in sub-Saharan Africa: A cross-sectional study. BMJ Global Health, 6(11), 1–11. https://doi.org/10.1136/bmjgh-2021-007225
Dana, R., Bannay, A., Bourst, P., Ziegler, C., Losser, M. R., Gibot, S., Levy, B., Audibert, G., & Ziegler, O. (2021). Obesity and mortality in critically ill COVID-19 patients with respiratory failure. International Journal of Obesity, 45(9), 2028–2037. https://doi.org/10.1038/s41366-021-00872-9
Dessie, Z. G., & Zewotir, T. (2021). Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infectious Diseases, 21(1). https://doi.org/10.1186/s12879-021-06536-3
Gao, M., Piernas, C., Astbury, N. M., Hippisley-Cox, J., O’Rahilly, S., Aveyard, P., & Jebb, S. A. (2021). Associations between body-mass index and COVID-19 severity in 6•9 million people in England: a prospective, community-based, cohort study. The Lancet Diabetes and Endocrinology, 9(6), 350–359. https://doi.org/10.1016/S2213-8587(21)00089-9
Goodman, K. E., Magder, L. S., Baghdadi, J. D., Pineles, L., Levine, A. R., Perencevich, E. N., & Harris, A. D. (2021). Impact of Sex and Metabolic Comorbidities on Coronavirus Disease 2019 (COVID-19) Mortality Risk Across Age Groups: 66 646 Inpatients Across 613 U.S. Hospitals. Clinical Infectious Diseases, 73(11), e4113–e4123. https://doi.org/10.1093/cid/ciaa1787
Kananen, L., Eriksdotter, M., Boström, A. M., Kivipelto, M., Annetorp, M., Metzner, C., Bäck Jerlardtz, V., Engström, M., Johnson, P., Lundberg, L. G., Åkesson, E., Sühl Öberg, C., Hägg, S., Religa, D., Jylhävä, J., & Cederholm, T. (2021). Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19. Clinical Nutrition, xxxx. https://doi.org/10.1016/j.clnu.2021.07.025
Kang, I. S., & Kong, K. A. (2021). Body mass index and severity/fatality from coronavirus disease 2019: A nationwide epidemiological study in Korea. PLOS ONE, 16(6), e0253640. https://doi.org/10.1371/journal.pone.0253640
Kelada, M., Anto, A., Dave, K., & Saleh, S. N. (2020). The Role of Sex in the Risk of Mortality From COVID-19 Amongst Adult Patients: A Systematic Review. Cureus, 12(8). https://doi.org/10.7759/cureus.10114
Kementerian Kesehatan RI. (2018). Hasil Riset Kesehatan Dasar Tahun 2018. Jakarta: Kementerian Kesehatann.
Kemenkes RI. (2021). Situasi Terkini COVID-19. https://www.kemkes.go.id/
Kompaniyets, L., Goodman, A. B., Belay, B., Freedman, D. S., Sucosky, M. S., Lange, S. J., Gundlapalli, A. V., Boehmer, T. K., & Blanck, H. M. (2021). Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020. MMWR Surveillance Summaries, 70(10), 355–361. https://doi.org/10.15585/mmwr.mm7010e4
Kooistra, E. J., Brinkman, S., van der Voort, P. H. J., de Keizer, N. F., Dongelmans, D. A., Kox, M., & Pickkers, P. (2021). Body Mass Index and Mortality in Coronavirus Disease 2019 and Other Diseases. Critical Care Medicine, Publish Ah. https://doi.org/10.1097/ccm.0000000000005216
Li, H., Wang, S., Zhong, F., Bao, W., Li, Y., Liu, L., Wang, H., & He, Y. (2020). Age-Dependent Risks of Incidence and Mortality of COVID-19 in Hubei Province and Other Parts of China. Frontiers in Medicine, 7(April), 1–6. https://doi.org/10.3389/fmed.2020.00190
Mahamat-Saleh, Y., Fiolet, T., Rebeaud, M. E., Mulot, M., Guihur, A., El Fatouhi, D., Laouali, N., Peiffer-Smadja, N., Aune, D., & Severi, G. (2021). Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: A systematic review and meta-analysis of observational studies. BMJ Open, 11(10). https://doi.org/10.1136/bmjopen-2021-052777
Malik, V. S., Ravindra, K., Attri, S. V., Bhadada, S. K., & Singh, M. (2020). Higher body mass index is an important risk factor in COVID-19 patients: a systematic review and meta-analysis. Environmental Science and Pollution Research, 27(33), 42115–42123. https://doi.org/10.1007/s11356-020-10132-4
Mertens, E., & Peñalvo, J. L. (2021). The Burden of Malnutrition and Fatal COVID-19: A Global Burden of Disease Analysis. Frontiers in Nutrition, 7(January), 1-12. https://doi.org/10.3389/fnut.2020.619850
Nguyen, N. T., Chinn, J., de Ferrante, M., Kirby, K. A., Hohmann, S. F., & Amin, A. (2021). Male gender is a predictor of higher mortality in hospitalized adults with COVID-19. PLoS ONE, 16(7 July), 1-6. https://doi.org/10.1371/journal.pone.0254066
Osi, A. A., Abdu, M., Muhammad, U., Ibrahim, A., Isma’il, L. A., Suleiman, A. A., Abdulkadir, H. S., Sada, S. S., Dikko, H. G., & Ringim, M. Z. (2020). A classification approach for predicting COVID-19 Patient’s survival outcome with machine learning techniques. MedRxiv. https://doi.org/10.1101/2020.08.02.20129767
Permana, H., Huang, I., Susandi, E., & Wisaksana, R. (2021). The association of admission random blood glucose concentration and body-mass index with mortality in COVID-19 patients. European Review for Medical and Pharmacological Sciences, 25(22), 7144-7150. https://doi.org/10.26355/eurrev_202111_27268
Plourde, G., Fournier-Ross, E., Tessier-Grenier, H., Mullie, L. A., Chassé, M., & Carrier, F. M. (2021). Association between obesity and hospital mortality in critical COVID-19: a retrospective cohort study. International Journal of Obesity, August, 30-32. https://doi.org/10.1038/s41366-021-00938-8
Sahin, S., Sezer, H., Cicek, E., Yaglz Ozogul, Y., Yildirim, M., Icli, T. B., Polat Korkmaz, O., Durcan, E., Sulu, C., Somay, K., Bekdemir, B., Borekci, S., Yazici, D., Deyneli, O., Ergonul, O., Tabak, F., Dikmen, Y., Ozkaya, H. M., Gonen, M. S., … Yumuk, V. D. (2021). The role of obesity in predicting the clinical outcomes of COVID-19. Obesity Facts, 14(5), 481-489. https://doi.org/10.1159/000517180
Santos, A., Magro, D. O., Evangelista-Poderoso, R., & Saad, M. J. A. (2021). Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications. Diabetology and Metabolic Syndrome, 13(1). https://doi.org/10.1186/s13098-021-00639-2
Sarmadi, M., Ahmadi-Soleimani, S. M., Fararouei, M., & Dianatinasab, M. (2021). COVID-19, body mass index and cholesterol: an ecological study using global data. BMC Public Health, 21(1), 1–14. https://doi.org/10.1186/s12889-021-11715-7
Sharma, J. R., & Yadav, U. C. S. (2021). COVID-19 severity in obese patients: Potential mechanisms and molecular targets for clinical intervention. Obesity Research and Clinical Practice, 15(2), 163-171. https://doi.org/10.1016/j.orcp.2021.01.004
Thinggaard, M., Jacobsen, R., Jeune, B., Martinussen, T., & Christensen, K. (2010). Is the relationship between bmi and mortality increasingly u-shaped with advancing age? A 10-year follow-up of persons aged 70-95 years. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65 A(5), 526–531. https://doi.org/10.1093/gerona/glp214
van Lieshout, S. H. J., Badás, E. P., Mason, M. W. T., Newman, C., Buesching, C. D., Macdonald, D. W., & Dugdale, H. L. (2020). Social effects on age-related and sex-specific immune cell profiles in a wild mammal. Biology Letters, 16(7), 20200234. https://doi.org/10.1098/rsbl.2020.0234
Wu, X., Li, C., Chen, S., Zhang, X., Wang, F., Shi, T., Li, Q., & Lin, L. (2021). Association of body mass index with severity and mortality of COVID-19 pneumonia: a two-center, retrospective cohort study from Wuhan, China. Aging, 13(6), 7767–7780. https://doi.org/10.18632/aging.202813
Yanez, N. D., Weiss, N. S., Romand, J. A., & Treggiari, M. M. (2020). COVID-19 mortality risk for older men and women. BMC Public Health, 20(1), 1–7. https://doi.org/10.1186/s12889-020-09826-8
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