Literature Review: Potensi Propolis Sebagai Imunomodulator

Authors

DOI:

https://doi.org/10.26630/jk.v13i3.2742

Keywords:

Flavonoid, Immunomodulator, Immune system, Propolis.

Abstract

Human immune system function can be enhanced with immunomodulators. One of the natural ingredients that have these properties is propolis. The use of propolis as an immunomodulator has not been widely used. This article aims to examine the potential of propolis as an immunomodulator. The method used is a literature review of research articles according to the theme and comes from the PubMed database, Google Scholar, and Science Direct. The article search strategy used the keywords flavonoid, immunomodulator, propolis, and the immune system. Propolis or bee glue is a resinous substance collected by honey bees from plant sources. The type of bee, the kind of plant habitat, the season, and geography will distinguish the chemical compounds of propolis. Propolis contains very high flavonoids as well as minerals, vitamins, and enzymes. Propolis from Indonesia has better flavonoid content than propolis from other countries. Flavonoids and Caffeic Acid Phenethyl Ester (CAPE) are the main ingredients that have the potential as immunomodulators in propolis. Propolis can be an immunomodulator because it can stimulate the phagocytosis process by macrophages, reduce the production of TNF- cytokines and inhibit complement. Propolis also increases the cytotoxicity of natural killer cells and stimulates antibody production.

Author Biography

Ginna Megawati, Universitas Padjadjaran

Divisi Gizi Medik Departemen Ilmu Kesehatan Masyarakat

References

Aden, A. Z., & Rifa’i, M. (2014). Bioactivity of Ethanolic Extract of Propolis (EEP) in Balb/C Mice’s CD4+CD25+ and B220+ Lymphocyte Cells. The Journal of Experimental Life Sciences, 4(2), 39–44. https://doi.org/10.21776/ub.jels.2014.004.02.03

Cuevas, A., Saavedra, N., Salazar, L. A., & Abdalla, D. S. P. (2013). Modulation of immune function by polyphenols: Possible contribution of epigenetic factors. Nutrients, 5(7), 2314–2332. https://doi.org/10.3390/nu5072314

Draganova-Filipova, M., Nikolova, M., Mihova, A., Peychev, L., & Sarafian, V. (2010). A pilot study on the immunomodulatory effect of bulgarian propolis. Biotechnology and Biotechnological Equipment, 24(May), 119–124. https://doi.org/10.1080/13102818.2010.10817824

El-gamal, Y. M., Elmasry, O. A., El-ghoneimy, D. H., & Soliman, I. M. (2011). Immunomodulatory effects of food. Egyptian Journal of Pediatric Allergy and Immunology (The), 9(1), 3–13.

Gao, W., Wu, J., Wei, J., Pu, L., Guo, C., Yang, J., … Luo, H. (2014). Brazilian Green Propolis Improves Immune Function in Aged Mice. Journal of Clinical Biochemistry and Nutrition, 55(1), 7–10. https://doi.org/10.3164/jcbn.13-70

Hasan, A. E. Zainal, Artika, I. M., Fatoni, A., & Haryanto, B. (2011). Antibacterial Activity Of Propolis Trigona Spp. From Bukjttinggi West Sumatera Against Salmonella Sp. Chem. Prog, 4(2), 55–59. https://doi.org/10.35799/cp.4.2.2011.4974

Hasan, Akhmad Endang Zainal, Mangunwidjaja, D., Sunarti, T. C., Suparno, O., & Setiyono, A. (2013). Optimasi Ekstraksi Propolis Menggunakan Cara Maserasi Dengan Pelarut Etanol 70% Dan Pemanasan Gelombang Mikro Serta Karakterisasinya Sebagai Bahan Antikanker Payudara. Jurnal Teknologi Industri Pertanian, 23(1), 13–21.

Kalia, P., Kumar, N. R., & Harjai, K. (2014). Studies on the effect of ethanolic extract of propolis in BALB/c mice. Journal of Applied and Natural Science, 6(2), 638–643.

Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: An overview. The Scientific World Journal, 2013. https://doi.org/10.1155/2013/162750

Mukherjee, P. K., Nema, N. K., Bhadra, S., Mukherjee, D., Braga, F. C., & Matsabisa, M. G. (2014). Immunomodulatory leads from medicinal plants. Indian Journal of Traditional Knowledge, 13(2), 235–256.

Mustafiah, S. E., Fatmawati, D., & Yusuf, I. (2011). Indeks Daya Fagosit Makrofag Peritoneum setelah Pemberian Propolis pada Mencit ( Mus musculus ). Prpopolis Sebagai Imunomodulator, 3(2), 121–128.

Nassar, S. A., Mohamed, A. H., Soufy, H., Nasr, S. M., & Mahran, K. M. (2012). Immunostimulant effect of Egyptian propolis in rabbits. The Scientific World Journal, 2012. https://doi.org/10.1100/2012/901516

Patil, U. S., Jaydoekar, A. ., & Bandawane, D. D. (2012). Immunomodulators: A Pharmacological Review. International Journal of Pharmacy and Pharmaceutical Sciences, 4(Suppl 1), 30–36.

Sforcin, J. M. (2007). Propolis and the immune system: a review. Journal of Ethnopharmacology, 113(1), 1–14. https://doi.org/10.1016/j.jep.2007.05.012

Sforcin, José Maurício, & Bankova, V. (2011). Propolis: Is there a potential for the development of new drugs? Journal of Ethnopharmacology, 133(2), 253–260. https://doi.org/10.1016/j.jep.2010.10.032

Suhirman, S., & Winarti, C. (2010). Prospek dan fungsi tanaman obat sebagai imunomodulator. Balai Penelitian Tanaman Obat dan Aromatik. hal, 121-131. https://www.academia.edu/download/37067837/4Obat.pdf

Syafrizal, Tarigan, D., & Yusuf, R. (2014). Keragaman dan Habitat Lebah Trigona pada Hutan Sekunder Tropis Basah di Hutan Pendidikan Lempake, Samarinda, Kalimantan Timur. Jurnal Teknologi Pertanian, 9(1), 34–38.

Syamsudin, Dewi, R. M., & Kusmardi. (2009). Immunomodulatory and In vivo Antiplasmodial Activities of Propolis Extracts. American Journal of Pharmacology and Toxicology, 4(3), 75–79.

Wagh, V. D. (2013). Propolis: A wonder bees product and its pharmacological potentials. Advances in Pharmacological Sciences, 2013. https://doi.org/10.1155/2013/308249

Warrington, R., Watson, W., Kim, H. L., & Antonetti, F. R. (2011). An introduction to immunology and immunopathology. Allergy, Asthma, and Clinical Immunology, 7(Suppl 1), S1. https://doi.org/10.1186/1710-1492-7-S1-S1

Yatim, K. M., & Lakkis, F. G. (2015). A Brief Journey Through The Immune System. Clinical Journal of the American Society of Nephrology : CJASN, 10(7), 1274–1281. https://doi.org/https://doi.org/10.2215/CJN.10031014

Yeap, S. K., Rahman, M. B. A., Alitheen, N. B., Ho, W. Y., Omar, A. R., Beh, B. K., & Ky, H. (2011). Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study. American Journal of Immunology, 7(2), 17–23.

Yuliana, N. D., Wijaya, C. H., & Nasrullah, N. (2013). Classification of Trigona spp bee propolis from four regions in Indonesia using FTIR metabolomics approach. 13th Asean Food Conference 2013, (September), 9–11.

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Published

13-12-2022

Issue

Vol. 13 No. 3 (2022): Jurnal Kesehatan

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Articles

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