Hubungan Indeks Massa Tubuh (IMT) dengan Ankle Brachial Index (ABI) pada Pasien Diabetes Mellitus Tipe 2 Etnis Jawa

Authors

  • Yanuarita Tursinawati Program Studi Kedokteran ,Universitas Muhammadiyah Semarang
  • Arum Kartikadewi Program Studi Kedokteran ,Universitas Muhammadiyah Semarang
  • Kamala Nuriyah Program Studi Kedokteran ,Universitas Muhammadiyah Semarang
  • Setyoko Setyoko Rumah Sakit Dr.Adhyatma, Semarang
  • Ari Yuniastuti Fakultas MIPA, Universitas Negeri Semarang

DOI:

https://doi.org/10.26630/jk.v11i2.1992

Keywords:

Ankle Brachial Index, Body Mass Index, Diabetes Mellitus.

Abstract

Diabetes mellitus (DM) often give a macrovascular complication such as Peripheral arterial disease (PAD). Ankle-brachial index (ABI) is a sensitive and specific examination for PAD. Obesity can be a risk factor of PAD. Obesity can be classified by the BMI (Body Mass Index) classification. The purpose of this research is to analyze the relationship of BMI with ABI in Type 2 DM (T2DM) patients of Javanese ethnicity. This study was an observational analytic research with case-control design and used a purposive sampling technique. There were 40 case samples and 40 control samples. Data analysis used the Independent T-test and Chi-square test. There was a significant differences on age (p=0,000), METs (p-value=0,003), and ABI (p-value=0,002) between the two groups. In the DM group was found that most abnormal ABIs were found in the higher BMI, even though there was no significant correlation by the statistic (p-value=0,255). BMI contributed less to the ABI value of Javanese ethnic T2DM patients.

Author Biographies

Yanuarita Tursinawati, Program Studi Kedokteran ,Universitas Muhammadiyah Semarang

Departement of Biomedics

Arum Kartikadewi, Program Studi Kedokteran ,Universitas Muhammadiyah Semarang

Department of Biomedics

Setyoko Setyoko, Rumah Sakit Dr.Adhyatma, Semarang

Departemen Ilmu Penyakit Dalam

References

Abouhamda, A., Alturkstani, M., & Jan, Y. (2019). Lower sensitivity of ankle-brachial index measurements among people suffering with diabetes-associated vascular disorders: A systematic review. SAGE Open Med., 7, 1-5. https://doi.org/10.1177/2050312119835038

Amati, F., Dubé, J. J., Coen, P. M., Stefanovic-Racic, M., Toledo, F. G. S., & Goodpaster, B. H. (2009). Physical inactivity and obesity underlie the insulin resistance of aging. Diabetes Care, 32(8), 1547–1549. https://doi.org/10.2337/dc09-0267

Aroor, A. R., Jia, G., & Sowers, J. R. (2018). Cellular mechanisms underlying obesity-induced arterial stiffness. Am J Physiol Integr Comp Physiol, 314(3), R387-R398. https://doi.org/10.1152/ajpregu.00235.2016

Bąk, E., Marcisz, C., Kadłubowska, M., Michalik, A., Krawczyk, B., Dobrzyń-Matusiak, D., Krzemińska, S., Fiałkowski, T., Glądys, E., & Drosdzol-Cop, A. (2016). Independent factors of changes of ankle-brachial index in peripheral arterial occlusive disease in elderly patients with or without diabetes. Int J Environ Res Public Health, 13(11), 1–11. https://doi.org/10.3390/ijerph13111103

Chaudru, S., De Müllenheim, P. Y., Le Faucheur, A., Kaladji, A., Jaquinandi, V., & Mahé, G. (2016). Training to perform ankle-brachial index: Systematic review and perspectives to improve teaching and learning. Eur J Vasc Endovasc Surg, 51(2), 240-247. https://doi.org/10.1016/j.ejvs.2015.09.005

Csige, I., Ujvárosy, D., Szabó, Z., Lorincz, I., Paragh, G., Harangi, M., Somodi, S., & Santulli, G. (2018). The Impact of Obesity on the Cardiovascular System. J Diabetes Res, 2018, 1-12.

https://doi.org/10.1155/2018/3407306

De Rekeneire, N., Peila, R., Ding, J., Colbert, L. H., Visser, M., Shorr, R. I., Kritchevsky, S. B., Kuller, L. H., Strotmeyer, E. S., Schwartz, A. V., Vellas, B., & Harris, T. B. (2006). Diabetes, hyperglycemia, and inflammation in older individuals: The Health, Aging and Body Composition study. Diabetes Care, 29(8), 1902–1908. https://doi.org/10.2337/dc05-2327

Erin E Horn, Turkheimer, E., & Duncan, G. E. (2015). Behavioral and environmental modification of the genetic influence on body mass index: A twin study. Behav Genet., 45(4), 409-426.

https://doi.org/10.1007/s10519-015-9718-6.

Fujita, Y., & Inagaki, N. (2017). Metformin: New Preparations and Nonglycemic Benefits. Curr. Diab. Rep., 17(5), 1–10. https://doi.org/10.1007/s11892-017-0829-8

Furukawa Y, Toji C, Fukui M, Kazumi T, Date C.(2009). The impact of sedentary lifestyle on risk factors for cardiovascular disease among Japanese young women. Nippon Koshu Eisei Zasshi,56:839-48.

Gerage, A. M., Correia, M. de A., de Oliveira, P. M. L., Palmeira, A. C., Domingues, W. J. R., Zeratti, A. E., Puech-Leão, P., Wolosker, N., Ritti-Dias, R. M., & Cucato, G. G. (2019). Physical activity levels in peripheral artery disease patients. Arq Bras Cardiol, 113(3), 410–416. https://doi.org/10.5935/abc.20190142

Handayani. (2012). Gambaran Pola Makan Suku Melayu Dan Suku Jawa Di Desa Selemak Kecamatan Hamparan Perak Kabupaten Deli Serdang Tahun 2012. [Skripsi]. Medan: Fakultas Kesehatan Masyarakat, Universitas Sumatera Utara.

Herningtya EH, Sheng T. (2019). Prevalence and distribution of metabolic syndrome and its components among provinces and ethnic groups in Indonesia. BMC Public Health,19:377.

IDF (International Diabetes Federation). (2017). IDF Diabetes Atlas : Eighth edition 2017. In IDF Diabetes Atlas, 8th edition. https://doi.org/http://dx.doi. org/10.1016/S0140-6736(16)31679-8.

IIleana Desormais , Victor Aboyans , Maëlenn Guerchet, Bébène Ndamba-Bandzouzi, Pascal Mbelesso, Julien Magne, Pierre Jesus, Benoît Marin, Philippe Lacroix, Pierre Marie Preux, E. investigators. (2020). Body Mass Index and Peripheral Arterial Disease, a “U-shaped†Relationship in Elderly African Population - The EPIDEMCA Study. VASA, 49(1), 50-56. https://doi.org/doi: 10.1024/0301-1526/a000825

Incalzi RA, Claudio P, Mary MM, Stefani B, Benedetta M, Raffaele ML et al. (2006). Association between nutrient intake and peripheral artery disease: Results from the InCHIANTI study. Atherosclerosis, 186 (1): 200-206.

doi:10.1016/j.atherosclerosis.2005.07.016.

Ishak AR, et al. (2014). Mutation of mtDNA ND1 Gene in 20 Type 2 Diabetes Mellitus Patients of Gorontalonese and Javanese Ethnicity. HAYATI J Biosci,12(4):159-65

Kementerian Kesehatan Republik Indonesia. (2014). Infodatin waspada Diabetes: Situasi dan Analisis Diabetes. http://www.depkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin-diabetes.pdf.

Kirwan, J. P., Krishnan, R. K., Weaver, J. A., Del Aguila, L. F., & Evans, W. J. (2001). Human aging is associated with altered TNF-α production during hyperglycemia and hyperinsulinemia. Am J Physiol Endocrinol Metab, 281(6 44-6), 1137–1143. https://doi.org/10.1152/ajpendo.2001.281.6.e1137

Maedler, K., Schumann, D. M., Schulthess, F., Oberholzer, J., Bosco, D., Berney, T., & Donath, M. Y. (2006). Aging correlates with decreased β-cell proliferative capacity and enhanced sensitivity to apoptosis: A potential role for fas and pancreatic duodenal homeobox-1. Diabetes, 55(9), 2455–2462. https://doi.org/10.2337/db05-1586

Marchio, P., Guerra-Ojeda, S., Vila, J. M., Aldasoro, M., Victor, V. M., & Mauricio, M. D. (2019). Targeting early atherosclerosis: A focus on oxidative stress and inflammation. Oxid. Med. Cell. Longev., 2019, 1–32. https://doi.org/10.1155/2019/8563845

Meadows JL, V. DE. (2011). Endothelial biology in the post-menopausal obese woman. Maturitas, 69, 120-125.

Muniyappa R, S. J. (2013). Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord, 14, 5-12.

Ogilvie RP, Pamela LL, Gerardo H,Aaron RF, Lyn MS. (2017). Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr,105:651-9.

Pingitore, A., Lima, G. P. P., Mastorci, F., Quinones, A., Iervasi, G., & Vassalle, C. (2015). Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports. Nutrition, 31(7-8), 916-922. https://doi.org/10.1016/j.nut.2015.02.005

Potier, L., Roussel, R., Labreuche, J., Marre, M., Cacoub, P., Röther, J., Wilson, P. W. F., Goto, S., Bhatt, D. L., & Steg, P. G. (2015). Interaction between diabetes and a high ankle-brachial index on mortality risk. Eur J Prev Cardiol., 22(5), 615–621. https://doi.org/10.1177/2047487314533621

Suprapti, D. (2018). Hubungan Pola Makan, Kondisi Psikologis, Dan Aktivitas Fisik Dengan Diabetes Mellitus Pada Lansia Di Puskesmas Kumai. Jurnal Borneo Cendekia, 2(1), 1-23.

Thiruvoipati, T. (2015). Peripheral artery disease in patients with diabetes: Epidemiology, mechanisms, and outcomes. World J Diabetes, 6(7), 961–969. https://doi.org/10.4239/wjd.v6.i7.961

Tursinawati, Y., Arum Kartikadewi, R. F. H. (2019). Association of CAPN10 SNP-19 ( rs3842570 ) Polymorphism on Fasting Plasma Glucose , Blood Pressure and Body Mass Index of Javanese Type-2 Diabetes Patients Association of CAPN10 SNP-19 ( rs3842570 ) Polymorphism on Fasting Plasma Glucose , Blood Pressure. IOP Conference Series: Earth and Environmental Science, 1-6.

Tursinawati, Y., Rifqi Fauzan Hakim, Afiana Rohmani, Arum Kartikadewi1, F. S. (2020). CAPN10 SNP-19 is Associated with Susceptibility of Type 2 Diabetes Mellitus: A Javanese Case-control Study. Indones Biomed J,12(2);109-114.

Widhiantara I. (2018). Fakta dan Angka Diabetes. Jurnal Kesehatan, 2, 10-15.

Downloads

Published

24-09-2020

Issue

Vol. 11 No. 2 (2020): Jurnal Kesehatan

Section

Articles

License

Authors who publish in this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.