Perbandingan Kepadatan Mineral Tulang Antar Pemakai Kontrasepsi Hormonal Progestin dan Kontrasepsi Non Hormonal pada Wanita Usia Subur

Aprilina Aprilina, Wiryawan Permadi, Elsa Pudji Setyawati, Farid Husin, Johanes C. Mose, Yudi Mulyana Hidayat


The decrease of bone mineral density will result in reducing bone strength tend to bone brittle so osteoporosis occurred. Osteoporosis affects 44 million people in the United States, 80% are women. It was assumed that progestin contraceptive acceptors decreased bone mineral density and increased the risk of osteoporotic fractures. The study used a comparative analytical method by using a cross-sectional study. The population was all acceptors progestin hormonal contraceptives (implants or injections) and acceptors of non-hormonal contraception (IUD or MOW) who came to the Public health center of Sekip Palembang and public health center of Basuki Rahmat in Palembang. The total sample was 200 respondents. The sample used purposive sampling, by using a consecutive sampling technique. The results were analyzed by using the Mann Whitney test and two ways ANOVA test directions with post hoc test and profile analysis. The results showed a significant difference in bone mineral density between the acceptors of progestin hormonal contraceptives and the acceptors of non- hormonal contraceptives to eligible women with ρ-value=0.001. There was a significant difference between acceptor of progestin hormonal contraceptives and non- hormonal contraceptives to eligible women referred to the duration of use, p-value of 1-2 years old was p-value=0.109, >2-3 years, p-value 0.039, and ≥3 years, p-value=0.033. Conclusion: there are differences in bone mineral density between acceptors of progestin hormonal contraceptives and acceptors of non-hormonal contraceptives to eligible women.


Bone mineral density; Progestin hormonal contraceptives; Non-hormonal contraception.

Full Text:



Badan Kependudukan dan Keluarga Berencana Nasional. (2012). Profil Hasil Pendataan Keluarga Tahun 2011. Jakarta: Badan Kependudukan dan Keluarga Berencana Nasional Direktorat Pelaporan dan Statistik.

Bahamondes, L., Monteiro-Dantas, C., Espejo-Arce, X., dos Santos Fernandes, A. M., Lui-Filho, J. F., Perrotti, M., & Petta, C. A. (2006). A prospective study of the forearm bone density of users of etonorgestrel-and levonorgestrel-releasing contraceptive implants. Human Reproduction, 21(2), 466-470.

Banks, E., Berrington, A., & Casabonne, D. (2001). Overview of the relationship between use of progestogen‐only contraceptives and bone mineral density. BJOG: An International Journal of Obstetrics & Gynaecology, 108(12), 1214-1221.

Blumenthal, P. D., & Edelman, A. (2008). Hormonal contraception. Obstetrics & Gynecology, 112(3), 670-684.

Cromer, B. A. (1999). Effects of hormonal contraceptives on bone mineral density. Drug safety, 20(3), 213-222.

Glasier, A., & Gebbie, A. (2006). Keluarga berencana dan kesehatan reproduksi. Jakarta: EGC.

Greenspan, F. S., & JD, B. (2000). Endokrinologi dasar dan klinik. EGC, Jakarta.

Herlina, E. C. (2000). Hubungan kontrasepsi hormonal dengan densitas mineral tulang pada wanita menopause dan pasca menopause. [Tesis], Semarang: Fakultas Kedokteran Universitas Diponegoro.

Jahari, A. B., & Prihatini, S. (2007). Risiko osteoporosis di Indonesia. Gizi Indonesia, 30(1).

Kawiyana IKS. (2009). Osteoporosis Pathogenesis Current Diagnosis and Treatment. Journal of Internal Medicine. 8(1):157-170.

Saifuddin, A. B. (2006). Buku panduan praktis pelayanan kontrasepsi. Jakarta: Yayasan Bina Pustaka Sarwono Prawirohardjo.

Shoepe, H. A., & Snow, C. M. (2005). Oral contraceptive use in young women is associated with lower bone mineral density than that of controls. Osteoporosis international, 16(12), 1538-1544.

World Health Organization. (2003). Prevention And Management Of Osteoporosis. Geneva, Switzerland: WHO scientific group.

Zhang, M. H., Zhang, W., Zhang, A. D., Yan, Y. A. N. G., & Ling, G. A. I. (2013). Effect of depot medroxyprogesterone acetate on bone mineral density in adolescent women. Chinese medical journal, 126(21), 4043-4047.



  • There are currently no refbacks.

Published by: Politeknik Kesehatan Tanjung Karang

ISSN Online 2548-5695 | ISSN Print 2086-7751
Jl. Soekarno-Hatta No. 6 Bandar Lampung Cq. Tim Jurnal Kesehatan Politeknik Kesehatan Tanjung Karang.
Telepon 0721-783852 Fax. 0721-773918, email:

Visitor Statistic :

View My Stats

Creative Commons License
Jurnal Kesehatan is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Flag Counter