Faktor Kejadian Anemia pada Pasien Kanker yang Mendapat Radioterapi dan atau Kemoterapi

Authors

  • Alpha Olivia Hidayati STIKES Guna Bangsa Yogyakarta Jl. Ring Road Utara, Condongcatur, Depok Sleman, DIY
  • Siti Arifah STIKES Guna Bangsa Yogyakarta Jl. Ring Road Utara, Condong Catur Depok Sleman Yogyakarta

DOI:

https://doi.org/10.26630/jk.v11i1.1629

Keywords:

Anemia, Cancer history, Nutrient intake, Radiotherapy, Therapy history.

Abstract

Base on research, radiotherapy can reduce cancer recurrence in 10 years from 35% to 19,3% in breast cancer. However, the therapy given affects the life quality of patients, one of which is anemia. Anemia causes a decrease in response and tolerance to treatment. This study aims to determine the factors associated with the incidence of anemia in cancer patients who receive radiotherapy and or chemotherapy. This study was an observational analytic study with a cross-sectional design. The method of sampling with consecutive sampling with a minimum sample size of 47. The result showed the age of a p-value (0,321)>0,05, the number of fractions a p-value (0,181)>0.05, the frequency of light that had been conducted a p-value (0,160)>0,05, type of radiotherapy a p-value (0,933)>0,05, setting radiotherapy a p-value (0,769)>0,05, history of blood transfusion during chemotherapy a p-value (0,411)>0,05 and nutrient intake (Protein a p-value (0,337)>0.05, iron a p-value (0,086)>0,05, zinc a p-value (0,411)>0,05, folic acid a p-value (0,963)>0,05, vitamin C a p-value (0,240)>0,05). Meanwhile, the total radiation dose received by respondents during one period of radiotherapy showed that there was a relationship with the incidence of anemia with a p-value (0,045)<0,05. As conclusions, that there was no significant relationship between age, type of cancer, number of fractions, frequency of light that had been conducted, type of radiotherapy, radiotherapy settings, history of blood transfusion during chemotherapy and nutrient intake, while the total radiation dose given to respondents showed a significant relationship with anemia incidence.

Author Biography

Alpha Olivia Hidayati, STIKES Guna Bangsa Yogyakarta Jl. Ring Road Utara, Condongcatur, Depok Sleman, DIY

Program Studi D3 Teknik Radiodiagnostik dan Radioterapi

References

Abdelhalim MA, Al-Ayed MS, Moussa SA, & Abd Al-Sheri Ael-H. (2015). The effects of gamma-radiation on red blood cell corpuscles and dimensional properties in rats. Pak J Pharm Sci. Sep;28(5 Suppl):1819-22.

Aditya E, & Gondhowiardjo SA. (2013). Hipofraksinasi pada kanker payudara stadium dini. Radioterapi dan Onkologi Indonesia. Vol. 4(2):53-60.

Alamsyah PR & Dini RA. (2016). Hubungan Kecukupan Zat Gizi dan Konsumsi Makanan penghambat Zat Besi dengan Kejadian Anemia pada Lansia. Media Gizi Indonesia. Vol 11(1). Hal: 48-54.

Andrew J, Bishop MD, Pamela KA, Larissa AM, Meyer MD, & Patricia JE. (2015). Relationship betwen low hemoglobin levels and outcames after treatment with radiation or chemoradiation in patients with cervical cancer: has the impact of anemia been overstated? International Journal of Radiation Oncology, Biology, Phisics. Vol 91(1); PP196-205.

Badan Penelitian dan Pengembangan Kesehatan Kemenkes RI. (2013). Riset Kesehatan Dasar (RISKESDAS) 2013. Badan Penelitian dan Pengembangan Kesehatan Kemenkes RI. Hal: 85-86.

Dicato M. (2003). Anemia in cancer:some phatophysiologi aspects. Oncologist. Vol. 8 (1) PP:19-21.

Gallagber M. (2012). The Nutrients and Their Metabolism in: Krause’s Food and Nutrition Theraphy. 13th ed. Missauri: Elsevier Inc. PP: 118-136.

Greg A. (2013). Cancer: 50 essential thing to do. Ed 4th. Plame. USA.

Gropper S, Smith J,& Groff J. (2009). Microminerals; In: Advance Nutrition and Human Metabolism. 5th. Canada-Wadsworth Cengage Learning. P: 376, 476, 477, 480, 483.

Harrison L, Daniel S, Lauren S, Carol W B, & Ramden Russel. (2001). Prevalence of anemia in cancer patients undergoing radiation therapy. Seminars in Oncology. Vol 28(2) (Suppl 8) PP:54-59.

Harrison LB. (2002). Impact of tumor hypoxia and anemia on radiation therapy outcames. Oncologist. Vol:7. PP: 492-508.

Maccio A, Clelia G, Carlo M, Luciana T, Maria CC, Carlo F, Itaru O, Antonio B & Tomas G. (2014). The role of inflamation, iron and nutritional status in cancer-related anemia: results of a large prospective observational study. Jorunal of Haematologica. Published Ahead of Print. On September 19. doi: 10.3324/haematol.2014.112813.

Nani D. (2009). Hubungan Umur Awal Menopouse dan Status Penggunaan Kontrasepsi hormonaldengan Kejadian Kanker Payudara. Jurnal Keperawatan Soedirman. Vol. 4(3). Hal: 102-106.

Nurjanah A,Etika R N, Niken, P, & Ahmad S. (2016). Hubungan jumlah fraksi radioterapi dengan kadar hemoglobin pasien kanker serviks di RSUP DR Kariadi. Journal of Nutrition College. Vol. 5(1). Hal: 1-7.

Priyanto LD. (2018). Hubungan Umur, Tingkat Pendidikan, dan Aktivitas Fisik Santriwati Husada dengan Anemia. Jurnal Berkala Epidemiologi. Vol. 6(2). Hal:139-146.

Rokom. (2017). Kementrian kesehatan ajak masyarakat cegah dan kendalikan kanker. http://sehatnegeriku.kemkes.go.id/baca/rilis-media/20170202/2119525/kementerian-kesehatan-ajak-masyarakat-cegah-dan-kendalikan-kanker/

Rouli N & Pustika A. (2005). Anemia pada penyakit keganasan anak. Sari Pediatri. Vol. 6(4). Hal: 176-181.

Spivak JL, Gascon P & Ludwig H. (2009). Anemia management in oncology and hematology. Oncologist. 14(Suppl 1). PP: 43-56.

Saptyasih AR, Laksmi W, & Nugraheni. (2016). Hubungan Asupan Zat Besi, Asam Folat, Vitamin B12, dan Vitamin C dengan Kadar Hemoglobin Siswa di SMP Negeri 2 Tawangharjo Kabupaten Grobogan. Jurnal Kesehatan Masyarakat. Vol. 4(4). Hal: 521-528.

Saydam. (2011). Memahami Berbagai Penyakit (Penyakit Pernapasan dan Gangguan Pencernaan). Bandung: Alfabeta.

Stauder, R., Valent, P., & Theurl, I. (2018). Anemia at older age: etiologies, clinical implications, and management. Blood, The Journal of the American Society of Hematology, 131(5), 505-514.

Stephen AR. (2017). Cancer: What You Need to Know. Stephen Rosenberg MD.LLC. Madison.PP :1-137.

Susworo R. (2007). Radioterapi. Dasar - Dasar Radioterapi. Tata Laksana Radioterapi Penyakit Kanker. Jakarta: Universitas Indonesia.

Wang Q, Ye T, Chen HL, Zhang XG, & Zhang LZ. (2016). Correlation between intensity modulated radiotherapy and bone marrow suppression in breast cancer. European Review for Medical and Pharmacological Sciences. Vol. 20.PP:75-81.

Downloads

Additional Files

Published

27-05-2020

Issue

Vol. 11 No. 1 (2020): Jurnal Kesehatan

Section

Articles

License

Authors who publish in this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.