Kaempferia galanga L. sebagai Anti-Inflamasi dan Analgetik
DOI:
https://doi.org/10.26630/jk.v10i3.1458Keywords:
Analgetic, Anti-inflammatory, Kaempferia galanga L.Abstract
Galangal (Kaempferia galanga l) is an herb that is often used in everyday life and widely used as a spice, food flavoring, and local tonic ingredients called ‘Jamu’. Galangal is a source of zinc, starch, ethyl ester, paraeumarin, borneaol, minerals, cinnamic acid, and other nutrients that are widely used in traditional medicine applications for a long time, especially in Southeast Asia. Besides that, it has medical functions, one of which is anti-inflammatory. Inflammation is a normal protective response to tissue injuries caused by physical trauma, damaging chemicals or microbiological substances. Inflammation can also be interpreted as the body's effort to activate or damage organisms that attack, eliminate irritants and regulate tissue repair. Signs of inflammation are redness, swelling, heat, and pain. Many chemical drugs are used to prevent inflammation, one of which is that modern drugs commonly used as anti-inflammatory drugs are NSAIDs (Non-Steroid Anti-inflammatory) Mechanism as an anti-inflammatory activity by elevating anti-inflammatory production IL-10, reducing pro-inflammatory IL-6 or TNF-a production, reducing the expression of iNOS and COX-2, inhibition of PG synthesis, Kaempferia galanga L also inhibits several inflammatory mediators TNF-α, IL-1β, and Nitric Oxide (NO) and angiogenesis.
References
Abbas, A. K., Lichtman, A. H., & Pillai, S. (2015). Cellular and Molecular Immunology. Canada: Elsevier Inc.
Aggarwal & Harikumar. (2009). Potential Therapeutic Effects of Curcumin, The Anti-Inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases. United States: NCBI.
Ashley, N. T., Weil, Z. M., & Nelson, R. J. (2012). Inflammation: Mechanisms, Costs, and Natural Variation. Annual Review Evol. Syst. 12(43): 385-406.
Asmara, A., Daili, S.F., Noegrohowati, T., & Zubaedah, I. (2012). Vehikulum dalam Dermatoterapi Topikal. Jakarta: Departemen Ilmu Farmasi Kedokteran FKUI.
Ayurini, B. D. (2010). Pengaruh Ekstrak Etanol Rimpang Kunyit (Curcuma domestica Val) terhadap Jumlah Geliatan Mencit BALB/C yang Diinjeksi Asam Asetat 0,1%. [Tesis]. Semarang: Universitas Diponegoro.
Bengmark, S. (2006). The Effect of Curcumin (Active Substance of Turmeric) on the Acetic-Acid Induced Visceral Nociception in Rats. J of Bio Sci. 11(2): 312–314.
Bonica, J.J. & Loeser, J. D. (2001). History of Pain Concepts and Therapies. Philadelphia: Lippincott William and Wilkins.
Buang, A. (2012). Uji Efek Anti Inflamasi Salep Ekstrak Etanol Rimpang Kunyit (Curcuma domestica rhizoma) terhadap Mencit (Mus musculus). J Media Farm. 9(16): 10–14.
Dhandapani, A., Kumar, S., & Kadarkarai, M. (2011). Larvicidal, Pupicidal and Smoke Toxicity Effect of Kaempferia Galanga to the Malarial Vector, Anopheles Stephensi. The BioScan J. 6(2): 329–333.
Dobelis. (2002). Curcuma longa. United states: Thorne Research, Inc.
Erlina, R., A. Indah, dan Yanwirasti. (2007). Efek Antiinflamasi Ekstrak Etanol Kunyit (Curcuma domestica Val.) pada Tikus Putih Jantan Galur Wistar. J. Sains dan Tekno Farm. 12(2): 112–115.
Gilman A.G., Hardman, J. G., & Limbird, L. E. (2001). The Pharmacological Basis of Therapeutics. New York: McGrawâ€Hill Medical Publishing Division.
Hasanah, N., Nazaruddin, F., Febriana, E., & Zuhrotun, A. (2011). Analisis Kandungan Minyak Atsiri dan Uji Aktivitas Antiinflamasi Ekstrak Rimpang Kencur (Kaempferia galanga L). J Matematika dan Sains. 16(3): 107–112.
Huang, L., Yagura, T., & Chen, S. (2008). Sedative activity of hexane extract of Kaempferia galangal L. and its active compound. J of Ethnopharm. 120(1): 123–125.
Izzany, F., Bakar, A., Fadzelly, M., Bakar, A., Abdullah, N., Endrini, S., & Rahmat, A. (2018). A Review of Malaysian Medicinal Plants with Potential Antidiabetic. Advances in Pharmacological Sciences. 10: 1-13.
Jagadish, P. C., Latha, K. P., Mudgal, J., & Nampurath, G. K. 2016. Extraction, characterization and evaluation of Kaempferia galanga L. (Zingiberaceae) rhizome extracts against acute and chronic inflammation in rats. J of Ethnopharm. 194(2): 434–439.
Katzung, B. G., Enthony, J. T., & Susan, B. M. (2013). Pharmacology: Examination and Board Review. 5th edition. United States: Lange Medical Book Mc. Graw-Hill.
Kusumawati, I., & Yusuf, H. (2011). Phospholipid Complex as a Carrier of Kaempferia Galanga Rhizome Extract to Improve Its Analgesic Activity. Int J of Pharm and Pharm Sci. 3(1): 1–3.
Linnet, A., Latha, P. G., Gincy, M. M., Anuja, G. I., Suja, S. R., & Shymal, S. (2010). Anti-inflammatory, Analgesic, and Anti-lipid Peroxidative Effects of Rhaphidophora pertusa (Roxb.) and Epipremnum pinnatum (Linn.) Engl. aerial parts. Indian J Nat Prod and Res. 1(1): 5–10
Majeed. (1995). Curcuminoids Antioxidant Phytonutrients. New Jersey: Nutrisciecs Publisher Inc.
Mohanbabu, V. A., Shanbhag, T., K. Kumari, M., Bairy, K. L., & Shenoy S. (2011). Evaluation of Antiinflammatory and Analgesic Activities of Alcoholic Extract of Kaempferia Galanga in Rats. Indian J Physiol Pharmacol. 55(1): 13–24.
Mueller, M., Hobiger, S., & Jungbauer, A. (2010). Anti-inflammatory activity of extracts from fruits, herbs and spices. J Food Chemistry. 122(4): 987-996.
Othman, R., Ibrahim, H., Mohd, M. A., Mustafa, M. R. & Awang, K. (2006). Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galangal L. J of Phytomed. 13(1): 61–66.
Ravi V., Saleem, T. S. M., Patel, S. S., Raamamurthy, J., & Gauthaman, K (2009). Anti-Inflammatory Effect of Methanolic Extract of Solanum nigrum Linn. Berries. Int J App Res Nat Prod. 2(2): 33–36.
Riasari, H., Rachmaniar, R., & Febriani, Y. (2016). Effectiveness of Anti-Inflammatory Plaster from Kencur (Kaempferia galanga L.) Rhizome Ethanol Extract. Int J of Pharm Sci and Res. 7(4): 1746–1749.
Rostiana, O., Abdullah, A., Taryono, & Haddad, E. A. (2003). Jenis-jenis Tanaman Obat. Jakarta: Penelitian Tanaman Rempah dan Obat.
Sukmono, R. J. (2009). Mengatasi Aneka Penyakit dengan Terapi Herbal. Jakarta: Agromedia Pustaka.
Sulaiman, M. R., Zakaria, Z. A., Daud, I. A., Ng, F. N., Ng, Y. C., & Hidayat, M. T. (2007). Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models. J of Nat Med. 62(2): 221–227.
Tara, V., Shanbag, Candrakala, S., Sachidananda, A., Kurady, B. L., Smita, S., & Ganesh, S. (2006). Wound Healing Activity of Alkoholic Extract of Kaempferia galanga in Wistar Rats. Indian J Physiol Pharmacol. 50(4): 384-390.
Tewtrakul, S., & Subhadhirasakul, S. (2008). Effects of compounds from Kaempferia parviflora on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha productions in RAW264.7 macrophage cells. J of Ethnopharm. 120(1): 81–84.
Umar, M. I., Asmawi, M. Z., Sadikun, A., Atangwho, I. J., Yam, M. F., Altaf, R., & Ahmed, A. (2012). Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts. J of Molecules. 17(7): 8720–8734.
Umar, M., Asmawi, M., Sadikun, A., Majid, A., Al-Suede, F., Hassan, L., Ahamed, M. (2014). Ethyl-p-methoxycinnamate isolated from kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. J of Clinics. 69(2): 134–144.
Vittalrao, Mohanbabu, A., Shanbhag, T., Kumari, K. M., Bairy, K. L., & Smita S. (2011). Evaluation of Antiinflammatory and Analgesic Activities of Alcoholic Extract of Kaempferia Galanga in Rats. Indian J of Phys and Pharm. 55(1): 13–24.
Downloads
Published
Issue
Section
License
Authors who publish in this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
