Pencegahan Transmisi Virus Hepatitis B pada Masa Perinatal

Aditya Bustami, Anita Anita

Abstract


Hepatitis adalah peradangan pada sel-sel hati, yang bisa disebabkan oleh infeksi (virus, bakteri, parasit), obat-obatan (termasuk obat tradisional), konsumsi alkohol, lemak yang berlebih dan penyakit autoimun . Indonesia merupakan salah satu negara di Asia tenggara yang menduduki salah satu negara dengan endemis  hepatitis. Metode dalam penulisan artikel ini adalah studi literatur (literature review).Wanita hamil dengan infeksi virus hepatitis B akut memiliki jalur yang tidak jauh berbeda dengan populasi orang dewasa, tetapi risiko penularan Hepatitis B ke neonatus meningkat pada masa kehamilan, saat infeksi akut terjadi.Infeksi Hepatitis B kronis biasanya dapat meningkat setelah melahirkan.Risiko penularan perinatal tertinggi pada wanita dengan tingkat viraemia tinggi; hal ini menjelaskan kegagalan imunoprofilaksis.Penularan terbesar terjadi kepada bayi yang dilahirkan oleh ibu dengan positif hepatitis B. Penularan terhadap bayi terjadi ketika masih dalam kandungan, saat melahirkan dan setelah persalinan. Pencegahan hepatitis B dapat dilakukan dengan melakukan skrining pada saat pemeriksaan kehamilan pertama.Untuk menurunkan angka transmisi penularan hepatitis B, dianjurkan ibu hamil dengan positif hepatitis B melakukan persalinan dengan metode sectio caesaria elektif.


Keywords


Hepatitis; Perinatal

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References


Ahmad, N, Kusnanto, H (2017). Prevalensi infeksi virus Hepatitis B pada bayi & anak yang dilahirkan ibu dengan HBsAg positif. Berita kedokteran Masyarakat Volume 33 No. 11 Tahun 2017. https://jurnal.ugm.ac.id/bkm/article/view/26310

American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 86: Viral Hepatitis in pregnancy. Obstetrics and gynecology. 2007;110(4), 941.

Budihusodo U. Hepatitis Akut pada Kehamilan. Dalam: Laksmi, Purwita W, Mansjoer A, Alwi I, Setiati S, et al. penyakit-penyakit pada kehamilan : peran seorang internis. Jakarta : Interna Publishing; 2008. hlm. 393-405.

Celen M, Mert D, Ay M, Dal T, Kaya S, Yildirim N, et al. Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection. World J Gastroenterol. 2013;19(48):9377-82.

Cheung KW, Seto MT, Wong SF. Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy. Eur J Obstetr Gynecol Reprod Biol. 2013;169(1):17-23

Chen HL, Lin LH, Hu FC, Lee JT, Lin WT, Yang YJ, et al. Effects of maternal screening and universal immunization to prevent mother- to-infant transmission of HBV. Gastroenterology. 2012;142(4):773-81

Dwivedi M, Misra SP, Misra V, Pandey A, Pant S, Singh R, Verma M. Seroprevalence of hepatitis B infection during pregnancy and risk of perinatal transmission. Indian Journal of Gastroenterology. 2011 Mar 1;30(2):66.

Ehrhardt S, Xie C, Guo N, Nelson K, Thio CL. Breastfeeding while taking lamivudine or tenofovir disoproxil fumarate: a review of the evidence. Clin Infect Dis. 2015:15;60(2):275-8.

Giles M, Visvanathan K, Lewin S, Sasadeusz J. Chronic hepatitis B infection and pregnancy. Obstetr Gynecol. 2012;67(1):37-44.

Goyal, A. Murray, J.M. (2014),The impact of vaccination and antiviral therapy on hepatitis B and hepatitis D epidemiology, P LoS One 9 (2014) e 110-143.

Greenup AJ, Tan PK, Nguyen V, Glass A, Davison S, Chatterjee U, et al. Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of hepatitis B virus. J Hepatol. 2014;61(3):502-7.

Han.G.R, Xu.C.L, Zhao.W, Yang.YF, (2012) Management of chronic hepatitis B in pregnancy, World J. Gastroenterol. WJG 18.

Honeck P, Weigel M, Kwon ST, Alken P, Bross S. Assisted procreation in cases of hepatitis B, hepatitis C or human immunodeficiency virus infection of the male partner. Hum Reprod. 2006;21(5):1117-21

Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Qiu JW. Studies on the integration of hepatitis B virus DNA sequence in human sperm chromosomes. Asian J Androl. 2002;4(3):209-12

Hu Y, Chen J, Wen J, Xu C, Zhang S, Xu B, et al. Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus. BMC Pregnancy Childbirth. 2013;13:119

Infodatin (2017). Situasi Penyakit Hepatitis B di Indonesia tahun 2017, ISSN 2442-7642

Kang W, Ding Z, Shen L, Zhao Z, Huang G, Zhang J, et al. Risk factors associated with immunoprophylaxis failure against mother to child transmission of hepatitis B virus and hepatitis B vaccination status in Yunnan province, China. Vaccine. 2014;32(27):3362-6

Khumaedi, AI, Gani, RA, Hasan, I (2016) Prevention of Hepatitis B Vertical Transmission: Focus on Antenatal Antiviral Administration. jurnal penyakit dalam vol 3 no 4 desember 2016

Kim HJ, Yoo HS, Kim JC, Park CS, Choi MS, Kim M, Choi H, Min JS, Kim YS, Yoon SW, Ahn JK.(2009). Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. Journal of ethnopharmacology. 2009 Jul 15;124(2):189-96.

La. Ma, Et all, 9 K.W.Cheung,M.T.Seto,S.F.Wong, Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy, Eur. J.Obstet. Gynecol. Reprod. Biol.169 (2013)17–23.

Lin X, Guo Y, Zhou A, Zhang Y, Cao J, Yang M, et al. Immunoprophylaxis failure against vertical transmission of hepatitis B virus in the Chinese population: a hospital-based study and a meta-analysis. Ped Infect Dis J. 2014;33(9):897-903.

Lu LL, Chen BX, Wang J, Wang D, Ji Y, Yi HG, et al. Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women. Int J Infect Dis. 2014;28:41-4

Lu Y, Liang XF, Wang FZ, Yan L, Li RC, Li YP, Zhu FC, Zhai XJ, Li J, Zhuang H. Hepatitis B vaccine alone may be enough for preventing hepatitis B virus transmission in neonates of HBsAg (+)/HBeAg (−) mothers. Vaccine. 2017 Jan 3;35(1):40-5.

Nelson NP, Jamieson DJ, Murphy TV. Prevention of Perinatal Hepatiti B Virus Transmission. J Ped Infect Dis. 2014;3(Suppl 1):S7-

Nie R, Jin L, Zhang H, Xu B, Chen W, Zhu G. Presence of hepatitis B virus in oocytes and embryos: a risk of hepatitis B virus transmission during in vitro fertilization. Fertil Steril. 2011;95(5):1667-71

Nguyen V, Tan PK, Greenup AJ, Glass A, Davison S, Samarasinghe D, et al. Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare. Aliment Pharmacol Ther. 2014;39(10):1225-34.

Ma. L, Alla.N.R, Li. X, Mynbaev.OA, Shi.Z, (2014) Mother-to child transmission of HBV: review of current clinical management and prevention strategies, Rev. Med.Virol.24(2014)396–406.

Merry, V. Pengelolaan Hepatitis B Dalam Kehamilan Dan Persalinan [Tesis]. Semarang : Obstetri dan Ginekologi Fakultas Kedokteran Universitas Diponegoro Semarang; 2001.

Pan CQ, Zou HB, Chen Y, Zhang X, Zhang H, Li J, et al. Cesarean section reduces perinatal transmission of hepatitis B virus infection from hepatitis B surface antigen-positive women to their infants. Clin Gastroenterol Hepatol. 2013;11(10):1349-55

Peraturan menteri kesehatan republik indonesia Nomor 52 tahun 2017 tentang eliminasi penularan human immunodeficiency virus, sifilis, dan hepatitis b dari ibu ke anak.

Practice Committee of American Society for Reproductive M. Recommendations for reducing the risk of viral transmission during fertility treatment with the use of autologous gametes: a committee opinion. Fertil Steril. 2013;99(2):340-6

Sanityoso, Andri. Hepatitis Viral Akut. Dalam : Sudoyo, Aru W. (2009), Buku Ajar Ilmu Penyakit Dalam Jilid I. Edisi ke-5. Jakarta: Pusat Penerbitan Departemen Ilmu Penyakit Dalam FKUI. hlm. 645-52.

Ter Borg MJ, Leemans WF, de Man RA, Janssen HL. Exacerbation of chronic hepatitis B infection after delivery. J Viral Hepatitis. 2008;15(1):37-41.

Tran TT. Hepatitis B in Pregnancy. Clin Infect Dis. 2016 Jun 1;62 Suppl 4(Suppl 4):S314-7. doi: 10.1093/cid/ciw092. PMID: 27190321; PMCID: PMC4889900.

WHO, 2016. Hepatitis B, https://www.who.int/news-room/fact-sheets/detail/hepatitis-b




DOI: http://dx.doi.org/10.26630/jkep.v15i2.1843

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