Perbedaan Kadar Protein Human Cpp (Copeptin) Berdasarkan Lama Menderita Pada Pasien Diabetes Melitus
DOI:
https://doi.org/10.26630/jak.v12i1.3704Keywords:
diabetes mellitus, copeptin, the length of timeAbstract
Diabetes mellitus is a big public health problem in Indonesia. The length of time of suffering from DM is associated with a decrease in the function of pancreatic beta cells resulting in insulin resistance, which occurs in type 2 diabetes mellitus. Insulin resistance can be determined by measuring copeptin levels. The aim of this study was to determine differences in levels of human CPP protein (copeptin) in diabetes mellitus patients based on length of suffering. This type of research is observational analytic with cross sectional research design. Samples were taken from diabetes mellitus outpatients at Roemani Muhammadiyah Hospital as many as 20 samples, then the samples were examined for levels of human CPP (copeptin) protein using the ELISA (Enzyme Linked Immunosorbent Assay) method. The results showed that the average copeptin level in patients with diabetes mellitus ≤ 3 years was 1054 pg/mL and the average copeptin level in patients with diabetes mellitus > 3 years was 899 pg/mL. Statistical tests using the Independent Sample T Test obtained a significant sig value of 0.027 with a significance level of 0.05, namely 0.027 <0.05 so that it can be concluded that there are differences in copeptin levels in diabetes mellitus patients based on length of suffering. Copeptin levels in patients with diabetes mellitus ≤ 3 years, namely 1054 pg/mL, were higher than copeptin levels in patients with diabetes mellitus > 3 years, namely 899 pg/mLReferences
Dobša, L., & Cullen Edozien, K. (2013). Copeptin and its potential role in diagnosis and prognosis of various diseases. Biochemia Medica, 23(2), 172–190.Elabscience, 2020. Human CPP (copeptin) ELISA Kit.
Elabscience, 2020, Human CPP (Copeptin) ELISA Kit. Catalog No.: E-EL-H0851.
Enhörning, S., Hedblad, B., Nilsson, P.M., Engstrom, G., Melander, O., Sweden, M., 2015. Copeptin is an independent predictor of diabetic heart disease and death. Am. Heart J. 169, 549-556.e1.
Fenske, W., Wanner, C., Allolio, B., Drechsler, C., Blouin, K., 2011. Copeptin Levels Associate with Cardiovascular Events in Patients with ESRD and Type 2 Diabetes Mellitus. J Am Soc Nephrol 22, 782–790. https://doi.org/10.1681/ASN.2010070691
Kelana, E., Nasrul, E., Yaswir, R., Desywar, 2015. Korelasi Indeks 20 /( C-Peptide Puasa × Glukosa Darah Puasa ) Dengan Homa-IR Untuk Menilai Resistensi Insulin Diabetes Melitus Tipe 2. J. MKA 38, 155–164.
Kementerian Kesehatan RI, 2020. Infodatin Tetap Produktif, Cegah, dan Atasi Diabetes Melitus 2020.https://www.kemkes.go.id/article/view/20 120100005/infodatin-tetap-produktif- cegah-dan-atasi-diabetes-melitus- 2020.html.
Kementerian Kesehatan RI, 2018. Hasil Utama Riskesda 2018.
Niamh Marriott, 2017. Blood marker can predict heart disease risk in type-2 diabetes patients.
Parkeni, 2018. Tetap Produktif Cegah dan Atasi Diabetes Militus.
Refardt, J., Winzeler, B., Crain, M.C., 2019. Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis. Juurnal Wiley 22–32. https://doi.org/10.1111/cen.13991
Riskesdas, 2018. Hari Diabetes Sedunia Tahun 2018. Kementerian. Kesehatan. Republik Indonesia.
Roussel, R., Boustany, R. El, Bouby, N., Potier, L., Fumeron, F., Mohammedi, K., Balkau, B., Tichet, J., Bankir, L., Marre, M., Velho, G., 2016. Plasma Copeptin , AVP Gene Variants , and Incidence of Type 2 Diabetes in a Cohort From the Community. J. Clin Endocrinol Metab 101, 2432–2439.https://doi.org/10.1210/jc.2016-1113
Saleem, U., Khaleghi, M., Morgenthaler, N.G., Bergmann, A., Struck, J., Mosley, T.H., Kullo, I.J., 2009. Plasma carboxy-terminal provasopressin (copeptin): A novel marker of insulin resistance and metabolic syndrome. J. Clin. Endocrinol. Metab. 94, 2558–2564. https://doi.org/10.1210/jc.2008-2278 Setiati, S., Alwi, I., Sudoyo, A.W., Simadibrata
Suyono, 2011. Penatalaksanaan Diabetes Melitus Terpadu. Penerbit FK Universitas Indonesia, Jakarta.
Tenderenda-Banasiuk, E., Wasilewska, A., Filonowicz, R., Jakubowska, U., Waszkiewicz-Stojda, M., 2014. Serum copeptin levels in adolescents with primary hypertension. Pediatr. Nephrol. 29, 423–429.https://doi.org/10.1007/s00467-013-2683- 5
Uzun, F., Biyik, I., Akturk, I.F., Yalcin, A.A.,Erturk, M., Oner, E., Kalkan, A.K., Yalcin, B., Atmaca, H., 2015. Serum copeptin levels in predicting nondippers in newly diagnosed hypertension. Blood Press. Monit. 20,199–203. https://doi.org/10.1097/MBP.0000000000 000123
Wannamethee, S.G., Welsh, P., Papacosta, O., Lennon, L., Whincup, P.H., Sattar, N., 2015. Copeptin, insulin resistance, and risk of incident diabetes in older men. J. Clin. Endocrinol. Metab. 100, 3332–3339. https://doi.org/10.1210/JC.2015-2362
Winzeler, B., Cesana-nigro, N., Refardt, J., Vogt, D.R., Imber, C., Morin, B., Popovic, M., Steinmetz, M., 2019. Articles Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus : a prospective diagnostic study. Lancet 6736, 1–9. https://doi.org/10.1016/S0140- 6736(19)31255-3
Zhou, Y., Colombo, G., Carai, M.A.M., Ho, A., Gessa, G.L., 2011. Involvement of Arginine Vasopressin and V1b Receptor in Alcohol Drinking in Sardinian Alcohol- Preferring Rats 35, 1876–1883. https://doi.org/10.1111/j.1530- 0277.2011.01532.x
Downloads
Published
Issue
Section
License
Jurnal Analisis Kesehatan is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Based on a work at https://ejurnal.poltekkes-tjk.ac.id/index.php/JANALISKES.
